ArticleAmerican journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists2015
Potential cytochrome P-450 drug-drug interactions in adults with metastatic solid tumors and effect on eligibility for Phase I clinical trials.
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In one paragraph
Article in American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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0cells of the map it votes in
8citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Impact of Medication Reconciliation in Oncology Early Phase Studies: A Drug-Drug Interaction Retrospective Study.JCO oncology practice · 2024Article
- Navigating the challenges of clinical trial professionals in the healthcare sector.Frontiers in medicine · 2024Review
- Clinical outcomes of concomitant use of proton pump inhibitors and regorafenib in patients with metastatic colorectal cancer: a multicenter study.European journal of clinical pharmacology · 2022Article
- Evaluation of Clinical Pharmacy Services for Phase 1 Clinical Trials.Journal of hematology oncology pharmacy · 2022Article
- Article
- Improvement Initiative to Develop and Implement a Tool for Detecting Drug-Drug Interactions During Oncology Clinical Trial Enrollment Eligibility Screening.Journal of patient safety · 2021Article
- Prevalence of drug-drug interactions in oncology patients enrolled on National Clinical Trials Network oncology clinical trials.BMC cancer · 2018Article
- Drug interaction screening in SWOG clinical trials.American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists · 2018Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 3 countries.
Kari B WisinskiKari B. Wisinski, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, University of Wisconsin (UW), Madison, and Assistant Professor, UW Carbone Cancer Center, Madison. Colby A. Cantu, B.S., is Medical Student, School of Medicine and Public Health, UW. Jens Eickhoff, Ph.D., is Senior Scientist, Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, UW. Kurt Osterby, B.S., is Senior Decision Support Analyst, UW Hospital and Clinics, Madison. Amye J. Tevaarwerk, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, UW, and Assistant Professor, UW Carbone Cancer Center. Jennifer Heideman, R.N., is Program Manager, School of Medicine and Public Health, UW, and Program Manager, UW Carbone Cancer Center. Glenn Liu, M.D., is Associate Professor of Medicine, School of Medicine and Public Health, UW, and UW Carbone Cancer Center. George Wilding, M.D., is Professor of Medicine, School of Medicine and Public Health, UW, and Professor, UW Carbone Cancer Center. Susan Johnston, Pharm.D., is Pharmaceutical Research Center Manager, UW Carbone Cancer Center, and UW Hospital and Clinics. Jill M. Kolesar, Pharm.d., is Professor of Pharmacy, School of Pharmacy, UW, and Faculty Supervisor, Analytical Laboratory for Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics, UW Carbone Cancer Center. kbwisinski@medicine.wisc.edu.
Colby A CantuKari B. Wisinski, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, University of Wisconsin (UW), Madison, and Assistant Professor, UW Carbone Cancer Center, Madison. Colby A. Cantu, B.S., is Medical Student, School of Medicine and Public Health, UW. Jens Eickhoff, Ph.D., is Senior Scientist, Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, UW. Kurt Osterby, B.S., is Senior Decision Support Analyst, UW Hospital and Clinics, Madison. Amye J. Tevaarwerk, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, UW, and Assistant Professor, UW Carbone Cancer Center. Jennifer Heideman, R.N., is Program Manager, School of Medicine and Public Health, UW, and Program Manager, UW Carbone Cancer Center. Glenn Liu, M.D., is Associate Professor of Medicine, School of Medicine and Public Health, UW, and UW Carbone Cancer Center. George Wilding, M.D., is Professor of Medicine, School of Medicine and Public Health, UW, and Professor, UW Carbone Cancer Center. Susan Johnston, Pharm.D., is Pharmaceutical Research Center Manager, UW Carbone Cancer Center, and UW Hospital and Clinics. Jill M. Kolesar, Pharm.d., is Professor of Pharmacy, School of Pharmacy, UW, and Faculty Supervisor, Analytical Laboratory for Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics, UW Carbone Cancer Center.
Jens EickhoffKari B. Wisinski, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, University of Wisconsin (UW), Madison, and Assistant Professor, UW Carbone Cancer Center, Madison. Colby A. Cantu, B.S., is Medical Student, School of Medicine and Public Health, UW. Jens Eickhoff, Ph.D., is Senior Scientist, Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, UW. Kurt Osterby, B.S., is Senior Decision Support Analyst, UW Hospital and Clinics, Madison. Amye J. Tevaarwerk, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, UW, and Assistant Professor, UW Carbone Cancer Center. Jennifer Heideman, R.N., is Program Manager, School of Medicine and Public Health, UW, and Program Manager, UW Carbone Cancer Center. Glenn Liu, M.D., is Associate Professor of Medicine, School of Medicine and Public Health, UW, and UW Carbone Cancer Center. George Wilding, M.D., is Professor of Medicine, School of Medicine and Public Health, UW, and Professor, UW Carbone Cancer Center. Susan Johnston, Pharm.D., is Pharmaceutical Research Center Manager, UW Carbone Cancer Center, and UW Hospital and Clinics. Jill M. Kolesar, Pharm.d., is Professor of Pharmacy, School of Pharmacy, UW, and Faculty Supervisor, Analytical Laboratory for Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics, UW Carbone Cancer Center.
Kurt OsterbyKari B. Wisinski, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, University of Wisconsin (UW), Madison, and Assistant Professor, UW Carbone Cancer Center, Madison. Colby A. Cantu, B.S., is Medical Student, School of Medicine and Public Health, UW. Jens Eickhoff, Ph.D., is Senior Scientist, Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, UW. Kurt Osterby, B.S., is Senior Decision Support Analyst, UW Hospital and Clinics, Madison. Amye J. Tevaarwerk, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, UW, and Assistant Professor, UW Carbone Cancer Center. Jennifer Heideman, R.N., is Program Manager, School of Medicine and Public Health, UW, and Program Manager, UW Carbone Cancer Center. Glenn Liu, M.D., is Associate Professor of Medicine, School of Medicine and Public Health, UW, and UW Carbone Cancer Center. George Wilding, M.D., is Professor of Medicine, School of Medicine and Public Health, UW, and Professor, UW Carbone Cancer Center. Susan Johnston, Pharm.D., is Pharmaceutical Research Center Manager, UW Carbone Cancer Center, and UW Hospital and Clinics. Jill M. Kolesar, Pharm.d., is Professor of Pharmacy, School of Pharmacy, UW, and Faculty Supervisor, Analytical Laboratory for Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics, UW Carbone Cancer Center.
Amye J TevaarwerkKari B. Wisinski, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, University of Wisconsin (UW), Madison, and Assistant Professor, UW Carbone Cancer Center, Madison. Colby A. Cantu, B.S., is Medical Student, School of Medicine and Public Health, UW. Jens Eickhoff, Ph.D., is Senior Scientist, Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, UW. Kurt Osterby, B.S., is Senior Decision Support Analyst, UW Hospital and Clinics, Madison. Amye J. Tevaarwerk, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, UW, and Assistant Professor, UW Carbone Cancer Center. Jennifer Heideman, R.N., is Program Manager, School of Medicine and Public Health, UW, and Program Manager, UW Carbone Cancer Center. Glenn Liu, M.D., is Associate Professor of Medicine, School of Medicine and Public Health, UW, and UW Carbone Cancer Center. George Wilding, M.D., is Professor of Medicine, School of Medicine and Public Health, UW, and Professor, UW Carbone Cancer Center. Susan Johnston, Pharm.D., is Pharmaceutical Research Center Manager, UW Carbone Cancer Center, and UW Hospital and Clinics. Jill M. Kolesar, Pharm.d., is Professor of Pharmacy, School of Pharmacy, UW, and Faculty Supervisor, Analytical Laboratory for Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics, UW Carbone Cancer Center.
Jennifer HeidemanKari B. Wisinski, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, University of Wisconsin (UW), Madison, and Assistant Professor, UW Carbone Cancer Center, Madison. Colby A. Cantu, B.S., is Medical Student, School of Medicine and Public Health, UW. Jens Eickhoff, Ph.D., is Senior Scientist, Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, UW. Kurt Osterby, B.S., is Senior Decision Support Analyst, UW Hospital and Clinics, Madison. Amye J. Tevaarwerk, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, UW, and Assistant Professor, UW Carbone Cancer Center. Jennifer Heideman, R.N., is Program Manager, School of Medicine and Public Health, UW, and Program Manager, UW Carbone Cancer Center. Glenn Liu, M.D., is Associate Professor of Medicine, School of Medicine and Public Health, UW, and UW Carbone Cancer Center. George Wilding, M.D., is Professor of Medicine, School of Medicine and Public Health, UW, and Professor, UW Carbone Cancer Center. Susan Johnston, Pharm.D., is Pharmaceutical Research Center Manager, UW Carbone Cancer Center, and UW Hospital and Clinics. Jill M. Kolesar, Pharm.d., is Professor of Pharmacy, School of Pharmacy, UW, and Faculty Supervisor, Analytical Laboratory for Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics, UW Carbone Cancer Center.
Glenn LiuKari B. Wisinski, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, University of Wisconsin (UW), Madison, and Assistant Professor, UW Carbone Cancer Center, Madison. Colby A. Cantu, B.S., is Medical Student, School of Medicine and Public Health, UW. Jens Eickhoff, Ph.D., is Senior Scientist, Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, UW. Kurt Osterby, B.S., is Senior Decision Support Analyst, UW Hospital and Clinics, Madison. Amye J. Tevaarwerk, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, UW, and Assistant Professor, UW Carbone Cancer Center. Jennifer Heideman, R.N., is Program Manager, School of Medicine and Public Health, UW, and Program Manager, UW Carbone Cancer Center. Glenn Liu, M.D., is Associate Professor of Medicine, School of Medicine and Public Health, UW, and UW Carbone Cancer Center. George Wilding, M.D., is Professor of Medicine, School of Medicine and Public Health, UW, and Professor, UW Carbone Cancer Center. Susan Johnston, Pharm.D., is Pharmaceutical Research Center Manager, UW Carbone Cancer Center, and UW Hospital and Clinics. Jill M. Kolesar, Pharm.d., is Professor of Pharmacy, School of Pharmacy, UW, and Faculty Supervisor, Analytical Laboratory for Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics, UW Carbone Cancer Center.
George WildingKari B. Wisinski, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, University of Wisconsin (UW), Madison, and Assistant Professor, UW Carbone Cancer Center, Madison. Colby A. Cantu, B.S., is Medical Student, School of Medicine and Public Health, UW. Jens Eickhoff, Ph.D., is Senior Scientist, Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, UW. Kurt Osterby, B.S., is Senior Decision Support Analyst, UW Hospital and Clinics, Madison. Amye J. Tevaarwerk, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, UW, and Assistant Professor, UW Carbone Cancer Center. Jennifer Heideman, R.N., is Program Manager, School of Medicine and Public Health, UW, and Program Manager, UW Carbone Cancer Center. Glenn Liu, M.D., is Associate Professor of Medicine, School of Medicine and Public Health, UW, and UW Carbone Cancer Center. George Wilding, M.D., is Professor of Medicine, School of Medicine and Public Health, UW, and Professor, UW Carbone Cancer Center. Susan Johnston, Pharm.D., is Pharmaceutical Research Center Manager, UW Carbone Cancer Center, and UW Hospital and Clinics. Jill M. Kolesar, Pharm.d., is Professor of Pharmacy, School of Pharmacy, UW, and Faculty Supervisor, Analytical Laboratory for Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics, UW Carbone Cancer Center.
Susan JohnstonKari B. Wisinski, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, University of Wisconsin (UW), Madison, and Assistant Professor, UW Carbone Cancer Center, Madison. Colby A. Cantu, B.S., is Medical Student, School of Medicine and Public Health, UW. Jens Eickhoff, Ph.D., is Senior Scientist, Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, UW. Kurt Osterby, B.S., is Senior Decision Support Analyst, UW Hospital and Clinics, Madison. Amye J. Tevaarwerk, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, UW, and Assistant Professor, UW Carbone Cancer Center. Jennifer Heideman, R.N., is Program Manager, School of Medicine and Public Health, UW, and Program Manager, UW Carbone Cancer Center. Glenn Liu, M.D., is Associate Professor of Medicine, School of Medicine and Public Health, UW, and UW Carbone Cancer Center. George Wilding, M.D., is Professor of Medicine, School of Medicine and Public Health, UW, and Professor, UW Carbone Cancer Center. Susan Johnston, Pharm.D., is Pharmaceutical Research Center Manager, UW Carbone Cancer Center, and UW Hospital and Clinics. Jill M. Kolesar, Pharm.d., is Professor of Pharmacy, School of Pharmacy, UW, and Faculty Supervisor, Analytical Laboratory for Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics, UW Carbone Cancer Center.
Jill M KolesarKari B. Wisinski, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, University of Wisconsin (UW), Madison, and Assistant Professor, UW Carbone Cancer Center, Madison. Colby A. Cantu, B.S., is Medical Student, School of Medicine and Public Health, UW. Jens Eickhoff, Ph.D., is Senior Scientist, Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, UW. Kurt Osterby, B.S., is Senior Decision Support Analyst, UW Hospital and Clinics, Madison. Amye J. Tevaarwerk, M.D., is Assistant Professor of Medicine, School of Medicine and Public Health, UW, and Assistant Professor, UW Carbone Cancer Center. Jennifer Heideman, R.N., is Program Manager, School of Medicine and Public Health, UW, and Program Manager, UW Carbone Cancer Center. Glenn Liu, M.D., is Associate Professor of Medicine, School of Medicine and Public Health, UW, and UW Carbone Cancer Center. George Wilding, M.D., is Professor of Medicine, School of Medicine and Public Health, UW, and Professor, UW Carbone Cancer Center. Susan Johnston, Pharm.D., is Pharmaceutical Research Center Manager, UW Carbone Cancer Center, and UW Hospital and Clinics. Jill M. Kolesar, Pharm.d., is Professor of Pharmacy, School of Pharmacy, UW, and Faculty Supervisor, Analytical Laboratory for Pharmacokinetics, Pharmacodynamics, and Pharmacogenomics, UW Carbone Cancer Center.
University of Wisconsin Carbone Cancer Center · USFaculty of Public Health · GBUniversity of Wisconsin–Madison · USUW Health University Hospital · US
Funding
UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI AMY TRENTHAM-DIETZ · 1985 to 2026
$142.6MWORD PROCESSORP30CA013330 · NCI · YESHIVA UNIVERSITY · PI THOMAS E ROHAN · 1985 to 2026
$111.2MInstitutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2MThe University of Rochester's Clinical and Translational Science InstituteUL1TR000042 · NCATS · UNIVERSITY OF ROCHESTER · PI BENNETT, NANCY M, KIEBURTZ, KARL D. · 2012 to 2015
$14.4MInstitutional Clinical and Translational Science Award (UW-Madison)KL2RR025012 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2007 to 2011
$11.1MPHASE I TRIALS OF ANTICANCER AGENTSU01CA062491 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI LIU, GLENN · 1994 to 2013
$7.6MInstitutional Clinical and Translational Science AwardKL2TR000428 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$6.2MNCATS NIH HHS KL2 TR000428NCATS NIH HHS UL1 TR000042NCATS NIH HHS UL1TR00042NCATS NIH HHS UL1 TR000427NCI NIH HHS P30 CA013330NCI NIH HHS P30 CA014520NCI NIH HHS U01 CA062491NCI NIH HHS U01 CA062491-19S1NCRR NIH HHS KL2 RR025012
Abstract
purposePotential cytochrome P-450 (CYP) drug-drug interactions in adults with metastatic solid tumors and their effect on eligibility for Phase I clinical trials were characterized.
methodsThis study included adult patients with metastatic solid tumors seen by a medical oncologist from January 2008 through July 2011. The medications used by these patients were identified. Each medication's potential for interacting with CYP isozymes was also characterized. Medication changes required to meet Phase I trial eligibility criteria were also reviewed.
resultsData from 1773 patients were analyzed: 1489 were not enrolled in a Phase I trial and 284 were enrolled in a Phase I trial. Polypharmacy was significantly more prevalent in the group enrolled in a Phase I trial compared with those not enrolled (95% versus 80%, p < 0.001). The majority of patients not enrolled in a Phase I trial were taking at least one CYP isozyme inhibitor (87%) and at least one CYP isozyme inducer (45%). In a separate analysis, four Phase I trials were evaluated. Of 295 screened patients, 3.2% could not enroll due to concurrent medications. Charts from 74 enrolled patients revealed 655 concurrent medications—93 medications required further review for eligibility involving 51 (69%) of patients. Of the 93 medications, 38 (41%) were stopped and 41 (44%) were changed for the study.
conclusionPolypharmacy and the use of medications that interact with CYP isoyzmes were common in adult patients with metastatic solid tumors. Patients enrolling in Phase I studies often require medication changes to meet eligibility requirements.
Indexed as
Patient SelectionAdolescentAdultAgedAged, 80 and overAntineoplastic AgentsClinical Trials, Phase I as TopicCytochrome P-450 Enzyme InducersCytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme SystemDrug InteractionsFemaleHumansMaleMiddle AgedNeoplasm MetastasisAntineoplastic AgentsCytochrome P-450 Enzyme InducersCytochrome P-450 Enzyme InhibitorsCytochrome P-450 Enzyme System
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