ArticleHypertension (Dallas, Tex. : 1979)2015
Elevated Endothelial Hypoxia-Inducible Factor-1α Contributes to Glomerular Injury and Promotes Hypertensive Chronic Kidney Disease.
Open access · greenAbstract read
In one paragraph
Article in Hypertension (Dallas, Tex. : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 65 citations in OpenAlex.
- Hypertension-Induced Renal Injury: From Pathophysiology to Therapeutic Perspectives.Biomedicines · 2026Review
- A Machine Learning Method for Predicting Acute Kidney Injury in Patients with Intracranial Hemorrhage.Cell biochemistry and biophysics · 2025Article
- The gut-kidney axis in high-altitude hypoxia: pathophysiological mechanisms and the central role of hypoxia inducible factor.Annals of medicine · 2025Review
- Characteristics and Outcomes of IgA Nephropathy Patients With SGLT2 Inhibitor-Induced Polycythemia.Cureus · 2025Article
- Moderate intensity continuous training mitigates hypertension-induced renal fibrosis by inhibiting HIF-1α-mediated autophagy.Frontiers in physiology · 2025Article
- Epigenetics of Hypertensive Nephropathy.Biomedicines · 2024Review
- Hypoxia-inducible factors and essential hypertension: narrative review of experimental and clinical data.Pharmacological reports : PR · 2023Review
- No benefit of HIF prolyl hydroxylase inhibition for hypertensive renal damage in renovascular hypertensive rats.Frontiers in physiology · 2023Article
- Hypoxia-inducible factor signaling in vascular calcification in chronic kidney disease patients.Journal of nephrology · 2022Review
- Pathological Connections between Nonalcoholic Fatty Liver Disease and Chronic Kidney Disease.Kidney diseases (Basel, Switzerland) · 2022Review
- Hypoxia-Inducible Factors and Diabetic Kidney Disease-How Deep Can We Go?International journal of molecular sciences · 2022Review
- Role of hypoxia preconditioning in therapeutic potential of mesenchymal stem-cell-derived extracellular vesicles.World journal of stem cells · 2022Review
- TIGAR deficiency sensitizes angiotensin-II-induced renal fibrosis and glomerular injury.Physiological reports · 2022Article
- Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis.Cell metabolism · 2022Article
- Coassembly of hypoxia-sensitive macrocyclic amphiphiles and extracellular vesicles for targeted kidney injury imaging and therapy.Journal of nanobiotechnology · 2021Article
- Intratubular, Intracellular, and Mitochondrial Angiotensin II/ATFrontiers in physiology · 2021Review
- Sodium-Glucose Cotransporter 2 Inhibitors Work as a "Regulator" of Autophagic Activity in Overnutrition Diseases.Frontiers in pharmacology · 2021Review
- Qian Yang Yu Yin Granule Improves Renal Injury of Hypertension by Regulating Metabolic Reprogramming Mediated by HIF-1α/PKM2 Positive Feedback Loop.Frontiers in pharmacology · 2021Article
- Pathogenesis and Damage Targets of Hypertensive Kidney Injury.Journal of translational internal medicine · 2020Article
- Effects of Allicin on Pathophysiological Mechanisms during the Progression of Nephropathy Associated to Diabetes.Antioxidants (Basel, Switzerland) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 2 countries.
Renna LuoFrom the Departments of Nephrology (R.L., L.T., Y.X.) and Urology (C.Z.), Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China; Departments of Biochemistry and Molecular Biology (R.L., W.Z., C.Z., Y.Z., H.W., J.J., R.E.K., Y.X.) and Internal Medicine (W.Z.), University of Texas Medical School at Houston; Program in Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, University of Texas, Houston (J.J., W.Z., R.E.K., Y.X.); and Department of Anesthesiology, University of Colorado-Medical School, Denver (A.G., H.K.E.).
Weiru ZhangFrom the Departments of Nephrology (R.L., L.T., Y.X.) and Urology (C.Z.), Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China; Departments of Biochemistry and Molecular Biology (R.L., W.Z., C.Z., Y.Z., H.W., J.J., R.E.K., Y.X.) and Internal Medicine (W.Z.), University of Texas Medical School at Houston; Program in Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, University of Texas, Houston (J.J., W.Z., R.E.K., Y.X.); and Department of Anesthesiology, University of Colorado-Medical School, Denver (A.G., H.K.E.).
Cheng ZhaoFrom the Departments of Nephrology (R.L., L.T., Y.X.) and Urology (C.Z.), Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China; Departments of Biochemistry and Molecular Biology (R.L., W.Z., C.Z., Y.Z., H.W., J.J., R.E.K., Y.X.) and Internal Medicine (W.Z.), University of Texas Medical School at Houston; Program in Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, University of Texas, Houston (J.J., W.Z., R.E.K., Y.X.); and Department of Anesthesiology, University of Colorado-Medical School, Denver (A.G., H.K.E.).
Yujin ZhangFrom the Departments of Nephrology (R.L., L.T., Y.X.) and Urology (C.Z.), Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China; Departments of Biochemistry and Molecular Biology (R.L., W.Z., C.Z., Y.Z., H.W., J.J., R.E.K., Y.X.) and Internal Medicine (W.Z.), University of Texas Medical School at Houston; Program in Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, University of Texas, Houston (J.J., W.Z., R.E.K., Y.X.); and Department of Anesthesiology, University of Colorado-Medical School, Denver (A.G., H.K.E.).
Hongyu WuFrom the Departments of Nephrology (R.L., L.T., Y.X.) and Urology (C.Z.), Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China; Departments of Biochemistry and Molecular Biology (R.L., W.Z., C.Z., Y.Z., H.W., J.J., R.E.K., Y.X.) and Internal Medicine (W.Z.), University of Texas Medical School at Houston; Program in Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, University of Texas, Houston (J.J., W.Z., R.E.K., Y.X.); and Department of Anesthesiology, University of Colorado-Medical School, Denver (A.G., H.K.E.).
Jianping JinFrom the Departments of Nephrology (R.L., L.T., Y.X.) and Urology (C.Z.), Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China; Departments of Biochemistry and Molecular Biology (R.L., W.Z., C.Z., Y.Z., H.W., J.J., R.E.K., Y.X.) and Internal Medicine (W.Z.), University of Texas Medical School at Houston; Program in Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, University of Texas, Houston (J.J., W.Z., R.E.K., Y.X.); and Department of Anesthesiology, University of Colorado-Medical School, Denver (A.G., H.K.E.).
Wenzheng ZhangFrom the Departments of Nephrology (R.L., L.T., Y.X.) and Urology (C.Z.), Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China; Departments of Biochemistry and Molecular Biology (R.L., W.Z., C.Z., Y.Z., H.W., J.J., R.E.K., Y.X.) and Internal Medicine (W.Z.), University of Texas Medical School at Houston; Program in Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, University of Texas, Houston (J.J., W.Z., R.E.K., Y.X.); and Department of Anesthesiology, University of Colorado-Medical School, Denver (A.G., H.K.E.).
Almut GrenzFrom the Departments of Nephrology (R.L., L.T., Y.X.) and Urology (C.Z.), Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China; Departments of Biochemistry and Molecular Biology (R.L., W.Z., C.Z., Y.Z., H.W., J.J., R.E.K., Y.X.) and Internal Medicine (W.Z.), University of Texas Medical School at Houston; Program in Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, University of Texas, Houston (J.J., W.Z., R.E.K., Y.X.); and Department of Anesthesiology, University of Colorado-Medical School, Denver (A.G., H.K.E.).
Holger K EltzschigFrom the Departments of Nephrology (R.L., L.T., Y.X.) and Urology (C.Z.), Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China; Departments of Biochemistry and Molecular Biology (R.L., W.Z., C.Z., Y.Z., H.W., J.J., R.E.K., Y.X.) and Internal Medicine (W.Z.), University of Texas Medical School at Houston; Program in Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, University of Texas, Houston (J.J., W.Z., R.E.K., Y.X.); and Department of Anesthesiology, University of Colorado-Medical School, Denver (A.G., H.K.E.).
Lijian TaoFrom the Departments of Nephrology (R.L., L.T., Y.X.) and Urology (C.Z.), Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China; Departments of Biochemistry and Molecular Biology (R.L., W.Z., C.Z., Y.Z., H.W., J.J., R.E.K., Y.X.) and Internal Medicine (W.Z.), University of Texas Medical School at Houston; Program in Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, University of Texas, Houston (J.J., W.Z., R.E.K., Y.X.); and Department of Anesthesiology, University of Colorado-Medical School, Denver (A.G., H.K.E.).
Rodney E KellemsFrom the Departments of Nephrology (R.L., L.T., Y.X.) and Urology (C.Z.), Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China; Departments of Biochemistry and Molecular Biology (R.L., W.Z., C.Z., Y.Z., H.W., J.J., R.E.K., Y.X.) and Internal Medicine (W.Z.), University of Texas Medical School at Houston; Program in Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, University of Texas, Houston (J.J., W.Z., R.E.K., Y.X.); and Department of Anesthesiology, University of Colorado-Medical School, Denver (A.G., H.K.E.).
Yang XiaFrom the Departments of Nephrology (R.L., L.T., Y.X.) and Urology (C.Z.), Xiangya Hospital of Central South University, Changsha, Hunan, P.R. China; Departments of Biochemistry and Molecular Biology (R.L., W.Z., C.Z., Y.Z., H.W., J.J., R.E.K., Y.X.) and Internal Medicine (W.Z.), University of Texas Medical School at Houston; Program in Biochemistry and Molecular Biology, Graduate School of Biomedical Sciences, University of Texas, Houston (J.J., W.Z., R.E.K., Y.X.); and Department of Anesthesiology, University of Colorado-Medical School, Denver (A.G., H.K.E.). yang.xia@uth.tmc.edu.
University of Houston · USCentral South University · CNXiangya Hospital Central South University · CN
Funding
Trangenic Mouse Breeding CoreP01HL114457 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ZHANG, YUJIN · 2013 to 2017
$10.0MPURINE METABOLISM AT THE MATERNAL/FETAL INTERFACER01HD034130 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KELLEMS, RODNEY E · 1996 to 2012
$2.8MExtracellular Adenosine During Ventilator Induced Lung InjuryR01HL092188 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ELTZSCHIG, HOLGER K. · 2009 to 2013
$2.1MAutoantibodies in Preeclampsia: Pre-symptomatic markers and therapeutic targetsRC4HD067977 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KELLEMS, RODNEY E, XIA, YANG · 2010 to 2010
$1.8MProton Pump Inhibitors for Perioperative Acute Kidney InjuryR01DK097075 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2013 to 2017
$1.7MHypoxia Inducible Factor in Acute Lung InjuryR01HL098294 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI ELTZSCHIG, HOLGER K. · 2011 to 2014
$1.6MAmphiregulin Signaling in Perioperative Cardio-ProtectionR01HL119837 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI ELTZSCHIG, HOLGER K. · 2014 to 2017
$1.5MMetabolites, Sickle Cell Disease, and Novel TherapeuticsR01HL113574 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XIA, YANG · 2013 to 2016
$1.5MAT1 Receptor Activating Autoantibodies and PreeclampsiaR01HL076558 · NHLBI · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI XIA, YANG · 2005 to 2008
$1.0MAngiotensin Receptor Autoantibodies and PreeclampsiaR56HD034130 · NICHD · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI KELLEMS, RODNEY E · 2007 to 2007
$371kNHLBI NIH HHS HL119549NHLBI NIH HHS P01 HL114457NHLBI NIH HHS P0I-HL114457NHLBI NIH HHS R01 HL076558NHLBI NIH HHS R01-HL092188NHLBI NIH HHS R01-HL098294NHLBI NIH HHS R01 HL113574NHLBI NIH HHS R01-HL119837NICHD NIH HHS HD34130NICHD NIH HHS R01 HD034130NICHD NIH HHS R56 HD034130NICHD NIH HHS RC4 HD067977NICHD NIH HHS RC4HD067977NIDDK NIH HHS R01 DK097075
Abstract
Hypertensive chronic kidney disease is one of the most prevalent medical conditions with high morbidity and mortality in the United States and worldwide. However, early events initiating the progression to hypertensive chronic kidney disease are poorly understood. We hypothesized that elevated endothelial hypoxia-inducible factor-1α (HIF-1α) is a common early insult triggering initial glomerular injury leading to hypertensive chronic kidney disease. To test our hypothesis, we used an angiotensin II infusion model of hypertensive chronic kidney disease to determine the specific cell type and mechanisms responsible for elevation of HIF-1α and its role in the progression of hypertensive chronic kidney disease. Genetic studies coupled with reverse transcription polymerase chain reaction profiling revealed that elevated endothelial HIF-1α is essential to initiate glomerular injury and progression to renal fibrosis by the transcriptional activation of genes encoding multiple vasoactive proteins. Mechanistically, we found that endothelial HIF-1α gene expression was induced by angiotensin II in a nuclear factor-κB-dependent manner. Finally, we discovered reciprocal positive transcriptional regulation of endothelial Hif-1α and Nf-κb genes is a key driving force for their persistent activation and disease progression. Overall, our findings revealed that the stimulation of HIF-1α gene expression in endothelial cells is detrimental to induce kidney injury, hypertension, and disease progression. Our findings highlight early diagnostic opportunities and therapeutic approaches for hypertensive chronic kidney disease.
Indexed as
Angiotensin IIAnimalsAntigens, CDCadherin 5CadherinsCells, CulturedDisease ProgressionEndothelial CellsEndothelin-1Endothelium, VascularFeedback, PhysiologicalFibrosisGene Expression RegulationHumansHypertensionHypoxia-Inducible Factor 1, alpha SubunitAngiotensin IIAntigens, CDCadherin 5CadherinsEndothelin-1HIF1A protein, humanHif1a protein, mouseHypoxia-Inducible Factor 1, alpha SubunitNF-kappa BRNA, Small Interferingangiotensin IIhypertensionhypoxia-inducible factor 1, alpharenal insufficiency, chronic
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.