ArticleAntimicrobial agents and chemotherapy2015
Clonal Dissemination of OXA-370-Producing Klebsiella pneumoniae in Rio de Janeiro, Brazil.
Article in Antimicrobial agents and chemotherapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed.
- Clonal overlap and resistance profiles of multidrug-resistantVeterinary world · 2025Article
- Genetic diversity, drug resistance, and biofilm formation in Klebsiella pneumoniae associated with nosocomial infection in Pelotas, RS, Brazil.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2023Review
- A Comprehensive Genomic Analysis of the EmergentPathogens (Basel, Switzerland) · 2022Article
- Characterization of Carbapenem-ResistantAntibiotics (Basel, Switzerland) · 2022Article
- Molecular Characterization of Carbapenem ResistantPathogens (Basel, Switzerland) · 2021Article
- An Emerging Clone, Klebsiellapneumoniae Carbapenemase 2-Producing K. pneumoniae Sequence Type 16, Associated With High Mortality Rates in a CC258-Endemic Setting.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
- Overestimated discriminatory power of MALDI-TOF mass spectrometry for typing of carbapenem-resistantEpidemiology and infection · 2019Article
- Clonal dissemination of KPC-2-producingAnnals of translational medicine · 2019Article
- Diversity of clonal types of Klebsiella pneumoniae causing infections in intensive care neonatal patients in a large urban setting.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- Rapid detection of the main carbapenemases in Brazil directly from spiked blood culture using the RESIST-3 O.K.N. immunoassay.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2019Article
- High Prevalence ofFrontiers in microbiology · 2018Article
- Genetic Platforms ofFrontiers in microbiology · 2018Article
- Dissemination of blaEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2017Article
- Clonal replacement of epidemic KPC-producing Klebsiella pneumoniae in a hospital in China.BMC infectious diseases · 2017Article
- Review
- Detection of Carbapenemase Genes in Aquatic Environments in Rio de Janeiro, Brazil.Antimicrobial agents and chemotherapy · 2016Article
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7 authors.
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Abstract
Enzymes of the OXA-48 family have become some of the most important beta-lactamases in the world. A new OXA-48 variant (OXA-370) was first described for an Enterobacter hormaechei strain isolated in Rio Grande do Sul (southern region of Brazil) in 2013. Here we report detection of the blaOXA-370 gene in 24 isolates belonging to three Enterobacteriaceae species (22 Klebsiella pneumoniae isolates, 1 Enterobacter cloacae isolate, and 1 Enterobacter aerogenes isolate) collected from five hospitals in Rio de Janeiro, Brazil, in 2013 and 2014. The isolates showed a multidrug resistance profile, and 12.5% were resistant to polymyxin B. Besides blaOXA-370, no other carbapenemase genes were observed by PCR, whereas blaOXA-1 was found in all isolates and 22 isolates (91.6%) possessed blaCTX-M-15. Molecular typing of the K. pneumoniae isolates by pulsed-field gel electrophoresis (PFGE) showed the presence of two clonal groups, i.e., KpA (21 isolates) and KpB (1 isolate). KpA was characterized as sequence type 16 (ST16) and KpB as ST1041 by multilocus sequence typing (MLST). ST16 has been observed for KPC-producing K. pneumoniae in Rio de Janeiro. Plasmid analysis performed with six representative OXA-370-producing isolates showed plasmids harboring the blaOXA-370 gene in all strains, ranging from 25 kb to 150 kb. This study suggests that there is an urgent need to investigate the presence of OXA-370 and dissemination of the K. pneumoniae ST16 clone carrying this gene in Brazil.
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