ReviewJournal of molecular evolution2015
Evolution of Enzyme Kinetic Mechanisms.
Review in Journal of molecular evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Chiral nanoenzymes: synthesis and applications.Mikrochimica acta · 2024Pooled it
- Phytochemicals and Irisin as Multi-Target Regulators of Adipose Tissue Browning and Metabolic Reprogramming: Synergies with GLP-1 Pathways.Antioxidants (Basel, Switzerland) · 2026Review
- Structural Determinants of Catalytic Bias in an AMP-Forming Acetyl-CoA Synthetase frombioRxiv : the preprint server for biology · 2026Article
- SIRT3/AARS2 regulates SOD2 lactylation to determine neuronal fate in TBI.Molecular neurobiology · 2026Article
- Glutathione-Coated Quantum Dots as Immobilized Substrates for the Evaluation of Glutathione-Dependent Enzymes: Glutathione Reductase and Glutathione S-Transferase.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Nano-enhanced Fenton/Fenton-like chemistry: integrating peroxidase nanozymes, MOFs, and MXenes for next-generation colorimetric biosensors.Nanoscale advances · 2025Review
- Discovery of a new bacterium, Microbacterium betulae sp. nov., in birch wood associated with hypersensitivity pneumonitis in woodworkers.Environmental microbiology reports · 2024Article
- Flux balance analysis-based metabolic modeling of microbial secondary metabolism: Current status and outlook.PLoS computational biology · 2023Review
- Kinetic data for modeling the dynamics of the enzymes involved in animal fatty acid synthesis.Bioscience reports · 2023Review
- Self-Organization of Enzyme-Catalyzed Reactions Studied by the Maximum Entropy Production Principle.International journal of molecular sciences · 2023Article
- Regulatory mechanisms controlling store-operated calcium entry.Frontiers in physiology · 2023Review
- Combatting antimicrobial resistance via the cysteine biosynthesis pathway in bacterial pathogens.Bioscience reports · 2022Review
- Kinetic and data-driven modeling of pancreatic β-cell central carbon metabolism and insulin secretion.PLoS computational biology · 2022Article
- Combined Theoretical and Experimental Study to Unravel the Differences in Promiscuous Amidase Activity of Two Nonhomologous Enzymes.ACS catalysis · 2021Article
- SCOUR: a stepwise machine learning framework for predicting metabolite-dependent regulatory interactions.BMC bioinformatics · 2021Article
- MASSpy: Building, simulating, and visualizing dynamic biological models in Python using mass action kinetics.PLoS computational biology · 2021Article
- Cyclic Changes in Active Site Polarization and Dynamics Drive the 'Ping-pong' Kinetics in NRH:Quinone Oxidoreductase 2: An Insight from QM/MM Simulations.ACS catalysis · 2018Article
- Structural and mechanistic analysis of a β-glycoside phosphorylase identified by screening a metagenomic library.The Journal of biological chemistry · 2018Article
- Formation of β-glucogallin, the precursor of ellagic acid in strawberry and raspberry.Journal of experimental botany · 2016Article
- Constraints, Trade-offs and the Currency of Fitness.Journal of molecular evolution · 2016Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This review paper discusses the reciprocal kinetic behaviours of enzymes and the evolution of structure-function dichotomy. Kinetic mechanisms have evolved in response to alterations in ecological and metabolic conditions. The kinetic mechanisms of single-substrate mono-substrate enzyme reactions are easier to understand and much simpler than those of bi-bi substrate enzyme reactions. The increasing complexities of kinetic mechanisms, as well as the increasing number of enzyme subunits, can be used to shed light on the evolution of kinetic mechanisms. Enzymes with heterogeneous kinetic mechanisms attempt to achieve specific products to subsist. In many organisms, kinetic mechanisms have evolved to aid survival in response to changing environmental factors. Enzyme promiscuity is defined as adaptation to changing environmental conditions, such as the introduction of a toxin or a new carbon source. Enzyme promiscuity is defined as adaptation to changing environmental conditions, such as the introduction of a toxin or a new carbon source. Enzymes with broad substrate specificity and promiscuous properties are believed to be more evolved than single-substrate enzymes. This group of enzymes can adapt to changing environmental substrate conditions and adjust catalysing mechanisms according to the substrate's properties, and their kinetic mechanisms have evolved in response to substrate variability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.