Evidence map›Paper›PMID 25987198›Full record

Trial reportComprehensive psychiatry2015

The effects of aggression on symptom severity and treatment response in a trial of cognitive behavioral therapy for panic disorder.

Clair Cassiello-Robbins, Laren R Conklin, Ujunwa Anakwenze, Jack M Gorman, Scott W Woods, M Katherine Shear, David H Barlow

Open access · greenAbstract readMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Comprehensive psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 19 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Clair Cassiello-RobbinsCenter for Anxiety and Related Disorders, Boston University, USA. Electronic address: ccassiel@bu.edu.
Laren R ConklinCenter for Anxiety and Related Disorders, Boston University, USA.
Ujunwa AnakwenzeCenter for Anxiety and Related Disorders, Boston University, USA.
Jack M GormanFranklin Behavioral Health Consultants, Bronx, NY, USA.
Scott W WoodsDepartment of Psychiatry, Yale University School of Medicine, USA.
M Katherine ShearDepartment of Psychiatry and School of Social Work, Columbia University, USA.
David H BarlowCenter for Anxiety and Related Disorders, Boston University, USA.
Boston University · USColumbia University · USYale University · US

Funding

Efficacy Evaluation of a Unified Transdiagnostic Treatment for Anxiety DisordersR01MH090053 · NIMH · BOSTON UNIVERSITY (CHARLES RIVER CAMPUS) · PI BARLOW, DAVID H. · 2011 to 2015
$2.9M
TREATMENT STUDY OF PANIC DISORDERR01MH045966 · NIMH · YALE UNIVERSITY · PI WOODS, SCOTT W · 1990 to 2003
$1.1M
TREATMENT STUDY OF PANIC DISORDERR01MH045965 · NIMH · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI BARLOW, DAVID H. · 1990 to 2003
$960k
NIMH NIH HHS R01 MH045965NIMH NIH HHS R01 MH045966NIMH NIH HHS R01 MH090053NIMH NIH HHS R01 MH45965
6 · The paper itself

Abstract

backgroundPrevious research suggests that patients with panic disorder exhibit higher levels of aggression than patients with other anxiety disorders. This aggression is associated with more severe symptomatology and interpersonal problems. However, few studies have examined whether higher levels of aggression are associated with a worse treatment response in this population.

methodsThe present study sought to examine the association of aggression with panic disorder symptom severity in a sample of 379 patients who participated in a trial examining long-term strategies for the treatment of panic disorder.

resultsWe found that aggression was significantly associated with higher baseline levels of panic disorder symptoms, anxiety, depression, and functional impairment. Further, we found that patients higher in aggression did not achieve the same level of improvement in general anxiety symptoms during treatment compared to patients lower in aggression, even when controlling for baseline anxiety symptom severity.

conclusionThese results suggest that more research is needed concerning patients with anxiety disorders with higher aggression, as they may be a group in need of additional treatment considerations.

Indexed as

Cognitive Behavioral TherapyAdolescentAdultAgedAggressionFemaleHumansMaleMiddle AgedPanic DisorderSeverity of Illness IndexSymptom AssessmentTreatment OutcomeYoung Adult

Identifiers

PMID25987198
PMCPMC4459913
OpenAlexW2028222476

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.