Observational studySaudi medical journal2015
Impact of maternal and neonatal factors on parameters of hematopoietic potential in umbilical cord blood.
Observational study in Saudi medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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Who cites it
6 citing papers in PubMed, 14 citations in OpenAlex.
- Development of a quantitative prediction algorithm for human cord blood-derived CD34Scientific reports · 2024Article
- Maternal and neonatal factors' effects on wharton's jelly mesenchymal stem cell yield.Scientific reports · 2024Article
- Effect of different timings of umbilical cord clamping on the level of CD34Scientific reports · 2023Article
- Evaluation of the Impact of Pregnancy-Associated Factors on the Quality of Wharton's Jelly-Derived Stem Cells Using SOX2 Gene Expression as a Marker.International journal of molecular sciences · 2022Article
- Impact of maternal and neonatal factors on umbilical cord CD34Stem cell investigation · 2020Article
- Human Umbilical Cord Blood CD34-Positive Cells as Predictors of the Incidence and Short-Term Outcome of Neonatal Hypoxic-Ischemic Encephalopathy: A Pilot Study.Journal of clinical neurology (Seoul, Korea) · 2017Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo determine characteristics of laboratory parameters of hematopoietic potential in umbilical cord blood and their association with maternal and neonatal factors.
methodsThis prospective analysis was performed on 206 umbilical cord blood donations (50-200 ml) from King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia between January and September 2014. Samples were processed and analyzed for total nucleated cells (TNC's), cluster designation (CD)45+, CD34+ counts, nucleated red blood cells (NRBCs) count, and viability testing.
resultsMost of the study participants (63.6%) were on their first 3 deliveries and from women with age between 17 and 30 years (80.6%). The donated volume was 50.4-192.4 ml, TNCs ranged from 500.2×106 to 9430.3 ×106 cells, and CD34+ cells ranged from 1.25×106 to 12.82×106/unit. The volume was positively affected by bigger birth weight of the baby (p less than 0.0001), larger placenta (p=0.001), TNCs (p less than 0.0001), CD34+ (p less than 0.0001), NRBCs (p less than 0.0001), and viability (p=0.002). There were no statistically significant differences between baby boys and girls for laboratory variables.
conclusionIn the selection and identification of a possible donor of umbilical cord blood, several maternal and neonatal factors should be considered, as younger maternal age, neonatal birth weight greater than 3300 grams, larger placental size, and first or second-born babies, were shown to be associated with higher TNCs, CD34+, CD45+, NRBCs, and viability.
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