ArticleGut2016
Adolescent body mass index and erythrocyte sedimentation rate in relation to colorectal cancer risk.
Article in Gut, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Early-onset colorectal cancer is associated with metabolic disorders: a systematic review and meta-analysis.European journal of epidemiology · 2026Pooled it
- Early-life anthropometry and colorectal cancer risk in adulthood: Global Cancer Update Programme (CUP Global) systematic literature review and meta-analysis of prospective studies.International journal of cancer · 2025Pooled it
- Overweight and obesity significantly increase colorectal cancer risk: a meta-analysis of 66 studies revealing a 25-57% elevation in risk.GeroScience · 2025Pooled it
- Pooled it
- Is the association of overweight and obesity with colorectal cancer underestimated? An umbrella review of systematic reviews and meta-analyses.European journal of epidemiology · 2023Pooled it
- Separating the effects of early and later life adiposity on colorectal cancer risk: a Mendelian randomization study.BMC medicine · 2023Pooled it
- Association of childhood and adolescence obesity with incidence and mortality of adulthood cancers. A systematic review and meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Association of Body Mass Index With Risk of Early-Onset Colorectal Cancer: Systematic Review and Meta-Analysis.The American journal of gastroenterology · 2021Pooled it
- Obesity and colorectal cancer risk: A systematic review and meta-analysis.World journal of clinical oncology · 2026Article
- Body size and occupational physical activity during the life course and gastrointestinal cancers.American journal of epidemiology · 2025Article
- Early-onset colorectal cancer as an emerging disease of metabolic dysregulation.Nature reviews. Endocrinology · 2025Review
- Review
- Clinical, Laboratory, Histological, Radiological, and Metabolic Features and Prognosis of Malignant Pleural Mesothelioma.Medicina (Kaunas, Lithuania) · 2022Article
- Body mass index-based predictions and personalized clinical strategies for colorectal cancer in the context of PPPM.The EPMA journal · 2022Review
- The timing of adiposity and changes in the life course on the risk of cancer.Cancer metastasis reviews · 2022Review
- A nomogram for predicting hyperprogressive disease after immune checkpoint inhibitor treatment in lung cancer.Translational lung cancer research · 2022Article
- Incidence of age migration of colorectal cancer in younger population: Retrospective single centred-population based cohort study.Annals of medicine and surgery (2012) · 2022Article
- Gut microbiome and its role in colorectal cancer.BMC cancer · 2021Review
- Review
- Colorectal cancer in the young - outcomes following surgical management?Annals of the Royal College of Surgeons of England · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
objectiveAdult obesity and inflammation have been associated with risk of colorectal cancer (CRC); however, less is known about how adolescent body mass index (BMI) and inflammation, as measured by erythrocyte sedimentation rate (ESR), relate to CRC risk. We sought to evaluate these associations in a cohort of 239 658 Swedish men who underwent compulsory military enlistment examinations in late adolescence (ages 16-20 years).
designAt the time of the conscription assessment (1969-1976), height and weight were measured and ESR was assayed. By linkage to the national cancer registry, these conscripts were followed for CRC through 1 January 2010. Over an average of 35 years of follow-up, 885 cases of CRC occurred, including 501 colon cancers and 384 rectal cancers. Cox regression was used to estimate adjusted HRs and corresponding 95% CIs.
resultsCompared with normal weight (BMI 18.5 to <25 kg/m(2)) in late adolescence, upper overweight (BMI 27.5 to <30 kg/m(2)) was associated with a 2.08-fold higher risk of CRC (95% CI 1.40 to 3.07) and obesity (BMI 30+ kg/m(2)) was associated with a 2.38-fold higher risk of CRC (95% CI 1.51 to 3.76) (p-trend: <0.001). Male adolescents with ESR (15+ mm/h) had a 63% higher risk of CRC (HR 1.63; 95% CI 1.08 to 2.45) than those with low ESR (<10 mm/h) (p-trend: 0.006). Associations did not significantly differ by anatomic site.
conclusionsLate-adolescent BMI and inflammation, as measured by ESR, may be independently associated with future CRC risk. Further research is needed to better understand how early-life exposures relate to CRC.
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