Evidence map›Paper›PMID 25986907›Full record

ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2015

Complex coevolution of depression and health-related quality of life in old age.

André Hajek, Christian Brettschneider, Annette Ernst, Carolin Lange, Birgitt Wiese, Jana Prokein, Siegfried Weyerer, Jochen Werle, Michael Pentzek, Angela Fuchs and 9 more

Abstract read
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In one paragraph

Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 1 country.

André HajekDepartment of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany. a.hajek@uke.de.
Christian BrettschneiderDepartment of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Annette ErnstDepartment of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Carolin LangeDepartment of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Birgitt WieseInstitute of General Practice, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Jana ProkeinInstitute of General Practice, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
Siegfried WeyererCentral Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J5, 68159, Mannheim, Germany.
Jochen WerleCentral Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, J5, 68159, Mannheim, Germany.
Michael PentzekInstitute of General Practice, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Angela FuchsInstitute of General Practice, Medical Faculty, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, 40225, Düsseldorf, Germany.
Janine SteinInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Ph.-Rosenthal-Str. 55, 04103, Leipzig, Germany.
Horst BickelDepartment of Psychiatry, Technical University of Munich, Arcisstr. 21, 80333, Munich, Germany.
Edelgard MöschDepartment of Psychiatry, Technical University of Munich, Arcisstr. 21, 80333, Munich, Germany.
Kathrin HeserDepartment of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.
Frank JessenDepartment of Psychiatry and Psychotherapy, University of Cologne, Kerpener Strasse 62, 50924, Cologne, Germany.
Wolfgang MaierDepartment of Psychiatry, University of Bonn, Sigmund-Freud-Str. 25, 53127, Bonn, Germany.
Martin SchererDepartment of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
Steffi G Riedel-HellerInstitute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Ph.-Rosenthal-Str. 55, 04103, Leipzig, Germany.
Hans-Helmut KönigDepartment of Health Economics and Health Services Research, Hamburg Center for Health Economics, University Medical Center Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Germany.
University Medical Center Hamburg-Eppendorf · DEGerman Center for Neurodegenerative Diseases · DEHeinrich Heine University Düsseldorf · DELeipzig University · DEMedizinische Hochschule Hannover · DETechnical University of Munich · DEUniversität Hamburg · DECentral Institute of Mental Health · DEHeidelberg University · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the coevolution of depression and health-related quality of life (HRQoL) in old age.

methodsIn a representative survey of the German general population aged 75 years and older, the course of HRQoL and depression was observed over 4.5 years (3 waves). HRQoL was assessed by the Visual Analogue Scale (EQ VAS) of the EQ-5D instrument, while the Geriatric Depression Scale was used to measure depression. A panel vector autoregressive model was used to account for the complex coevolution of depression and HRQoL. Unobserved heterogeneity was taken into account by taking the first differences.

resultsWe revealed a robust negative association between an initial change in HRQoL and a subsequent change in depression score, with substantial sex differences: In women there was a robust association, while in men the significance of this association depended on the model specification. Surprisingly, in the total sample and in both sexes, no robust association between an initial increase in depression and a subsequent change in HRQoL was found.

conclusionFindings indicate that the direction of evolution from HRQoL to depression deserves more attention. Furthermore, treatment of depression in late life should aim at improving HRQoL in which remission of depressive symptoms is necessary but not sufficient.

Indexed as

Health StatusAdultAgedAged, 80 and overDepressionFemaleHumansMaleQuality of LifeDepressionDepressive symptomsHealth-related quality of lifeLongitudinal studiesOlder peopleVector autoregressive model

Identifiers

PMID25986907
OpenAlexW253594275

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.