ReviewMedical molecular morphology2015
Double heterozygous mice for Klf5 and Fli1 genes: a new animal model of systemic sclerosis recapitulating its three cardinal pathological features.
Review in Medical molecular morphology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 7 citations in OpenAlex.
- Expression of collagen-related piRNA is dysregulated in cultured dermal fibroblasts derived from patients with scleroderma.Intractable & rare diseases research · 2023Article
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lack of animal models recapitulating the three cardinal features of systemic sclerosis (SSc), such as immune activation, vasculopathy, and tissue fibrosis, hinders the understanding of the pathogenesis of this disease. A series of clinical studies has suggested that environmental factors largely contribute to the development of SSc in individuals predisposed by genetic factors. This notion is supported by the establishment of a new murine SSc model which recapitulates three cardinal features of SSc by simultaneous haploinsufficiency of Klf5 and Fli1 genes, both of which are epigenetically suppressed in SSc dermal fibroblasts. In addition to enhanced dermal thickness, Klf5(+/-) and Fli1(+/-) mice resemble dermal fibrosis of SSc at the ultrastructural level. Furthermore, these mice simulate altered vascular structure and B cell activation characteristic of SSc. Further studies on the pathological events in Klf5(+/-) and Fli1(+/-) mice and the roles of KLF5 and Fli1 in various types of cells may provide us with a useful clue to better understand the developmental process of SSc.
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Registered trials
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