Evidence map›Paper›PMID 25986680›Full record

ArticleMedical molecular morphology2015

ATP-association to intrabacterial nanotransportation system in Vibrio cholerae.

Yuji Matsuzaki, Hong Wu, Takashi Nakano, Takashi Nakahari, Kouichi Sano

Erratum issuedAbstract read
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In one paragraph

Article in Medical molecular morphology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A low [CaPflugers Archiv : European journal of physiology · 2017
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yuji MatsuzakiDepartment of Microbiology and Infection Control, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-shi, Osaka, 569-8686, Japan.
Hong WuDepartment of Microbiology and Infection Control, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-shi, Osaka, 569-8686, Japan.
Takashi NakanoDepartment of Microbiology and Infection Control, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-shi, Osaka, 569-8686, Japan.
Takashi NakahariDepartment of Physiology, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-shi, Osaka, 569-8686, Japan.
Kouichi SanoDepartment of Microbiology and Infection Control, Osaka Medical College, 2-7 Daigaku-machi, Takatsuki-shi, Osaka, 569-8686, Japan. ksano@art.osaka-med.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vibrio cholerae colonizes the lumen of the proximal small intestine, which has an alkaline environment, and secretes cholera toxin (CT) through a type II secretion machinery. V. cholerae possesses the intrabacterial nanotransportation system (ibNoTS) for transporting CT from the inner portion toward the peripheral portion of the cytoplasm, and this system is controlled by extrabacterial pH. Association of ATP with ibNoTS has not yet been examined in detail. In this study, we demonstrated by immunoelectron microscopy that ibNoTS of V. cholerae under the extrabacterial alkaline condition was inhibited by ATP inhibitors, 2,4-dinitrophenol (DNP), a protonophore, or 8-amino-adenosine which produces inactive form of ATP. The inhibition of CT transport can be reversed by neutralization of DNP. Those inhibitions were associated with decrease of CT secretion by which ibNoTS followed. We propose that ATP closely associates with V. cholerae ibNoTS for transporting CT.

Indexed as

2,4-DinitrophenolAdenosineAdenosine TriphosphateBiological TransportCholera ToxinCytoplasmHumansHydrogen-Ion ConcentrationIntestine, SmallMicroscopy, ImmunoelectronType II Secretion SystemsUncoupling AgentsVibrio cholerae2,4-Dinitrophenol8-aminoadenosineAdenosineAdenosine TriphosphateCholera ToxinType II Secretion SystemsUncoupling AgentsATPCholera toxinImmunoelectron microscopyNanotransportationVibrio cholerae

Identifiers

PMID25986680

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.