Evidence map›Paper›PMID 25986641›Full record

Trial reportBMJ open2015

Protocol for the CHEST Australia Trial: a phase II randomised controlled trial of an intervention to reduce time-to-consult with symptoms of lung cancer.

Sonya R Murray, Peter Murchie, Neil Campbell, Fiona M Walter, Danielle Mazza, Emily Habgood, Yvonne Kutzer, Andrew Martin, Stephen Goodall, David J Barnes and 1 more

Open access · goldAbstract readClinical Trial, Phase IIRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Reducing Stigma in Lung Cancer Screening: Co-Design of a Targeted Resource for Health Professionals in Australia.Health expectations : an international journal of public participation in health care and health policy · 2026
    Article
  4. Article
  5. Article
  6. Improving early diagnosis of symptomatic cancer.Nature reviews. Clinical oncology · 2016
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Sonya R MurrayDepartment of General Practice, School of Primary, Aboriginal and Rural Health Care, The University of Western Australia, Crawley, Western Australia, Australia.
Peter MurchieThe Centre of Academic Primary Care, The University of Aberdeen, Aberdeen, UK.
Neil CampbellThe Centre of Academic Primary Care, The University of Aberdeen, Aberdeen, UK.
Fiona M WalterDepartment of General Practice, School of Primary, Aboriginal and Rural Health Care, The University of Western Australia, Crawley, Western Australia, Australia Department of General Practice, University of Melbourne, Melbourne, Victoria, Australia The Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Danielle MazzaDepartment of General Practice, Monash University, Melbourne, Victoria, Australia.
Emily HabgoodDepartment of General Practice, University of Melbourne, Melbourne, Victoria, Australia.
Yvonne KutzerDepartment of General Practice, School of Primary, Aboriginal and Rural Health Care, The University of Western Australia, Crawley, Western Australia, Australia.
Andrew MartinNHMRC Clinical Trials Centre, University of Sydney, New South Wales, Australia.
Stephen GoodallCentre for Health Economics Research and Evaluation (CHERE), University of Technology, Sydney, New South Wales, Australia.
David J BarnesRoyal Prince Alfred Hospital, Sydney, New South Wales, Australia Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Jon D EmeryDepartment of General Practice, School of Primary, Aboriginal and Rural Health Care, The University of Western Australia, Crawley, Western Australia, Australia Department of General Practice, University of Melbourne, Melbourne, Victoria, Australia The Primary Care Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-5274-6336
The University of Melbourne · AUThe University of Sydney · AUThe University of Western Australia · AUUniversity of Aberdeen · GBMonash University · AUUniversity of Technology Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionLung cancer is the most common cancer worldwide, with 1.3 million new cases diagnosed every year. It has one of the lowest survival outcomes of any cancer because over two-thirds of patients are diagnosed when curative treatment is not possible. International research has focused on screening and community interventions to promote earlier presentation to a healthcare provider to improve early lung cancer detection. This paper describes the protocol for a phase II, multisite, randomised controlled trial, for patients at increased risk of lung cancer in the primary care setting, to facilitate early presentation with symptoms of lung cancer. METHODS/ANALYSIS: The intervention is based on a previous Scottish CHEST Trial that comprised of a primary-care nurse consultation to discuss and implement a self-help manual, followed by self-monitoring reminders to improve symptom appraisal and encourage help-seeking in patients at increased risk of lung cancer. We aim to recruit 550 patients from two Australian states: Western Australia and Victoria. Patients will be randomised to the Intervention (a health consultation involving a self-help manual, monthly prompts and spirometry) or Control (spirometry followed by usual care). Eligible participants are long-term smokers with at least 20 pack years, aged 55 and over, including ex-smokers if their cessation date was less than 15 years ago. The primary outcome is consultation rate for respiratory symptoms. ETHICS AND DISSEMINATION: Ethical approval has been obtained from The University of Western Australia's Human Research Ethics Committee (RA/4/1/6018) and The University of Melbourne Human Research Committee (1 441 433). A summary of the results will be disseminated to participants and we plan to publish the main trial outcomes in a single paper. Further publications are anticipated after further data analysis. Findings will be presented at national and international conferences from late 2016. TRIAL REGISTRATION NUMBER: Australian New Zealand Clinical Trial Registry ACTRN 1261300039 3752.

Indexed as

Early Detection of CancerHealth BehaviorPrimary Health CareSelf CareAgedAustraliaDiagnostic Self EvaluationFemaleHumansLung NeoplasmsMaleMiddle AgedNursesPatient Acceptance of Health CareReferral and ConsultationResearch DesignONCOLOGYPREVENTIVE MEDICINEPRIMARY CAREPUBLIC HEALTH

Identifiers

PMID25986641
PMCPMC4442170
OpenAlexW1913031727

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.