Evidence map›Paper›PMID 25986629›Full record

ArticleJournal of diabetes science and technology2015

Predictors of Hypoglycemia in the ASPIRE In-Home Study and Effects of Automatic Suspension of Insulin Delivery.

Ram Weiss, Satish K Garg, Richard M Bergenstal, David C Klonoff, Bruce W Bode, Timothy S Bailey, James Thrasher, Frank Schwartz, John B Welsh, Francine R Kaufman and 1 more

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of diabetes science and technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01497938 (ASPIRE), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01497938 phase3completednot on this map

ASPIRE (Automation to Simulate Pancreatic Insulin Response): Pivotal In Home Study to Determine Safety and Efficacy of the LGS Feature in Sensor-augmented Pumps

TypeinterventionalSponsorMedtronic MiniMed, Inc.Ran2011 to 2013Enrolled247ConditionsType 1 DiabetesArmsMedtronic MMT-754 Veo Insulin pump testing Low Glucose Suspend (LGS) feature, Medtronic (NO LGS FEATURE ) using Paradigm® Revel™2.0 Pump
3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Impact of Chronic Sleep Disturbance for People Living With T1 Diabetes.Journal of diabetes science and technology · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Ram WeissDepartment of Human Metabolism and Nutrition, Hebrew University, and the Department of Pediatrics, Hadassah Medical Center, Jerusalem, Israel.
Satish K GargUniversity of Colorado Denver, Aurora, CO, USA.
Richard M BergenstalInternational Diabetes Center, Minneapolis, MN, USA.
David C KlonoffMills-Peninsula Health Services, San Mateo, CA, USA.
Bruce W BodeAtlanta Diabetes Associates, Atlanta, GA, USA.
Timothy S BaileyAMCR Institute, Escondido, CA, USA.
James ThrasherArkansas Diabetes and Endocrinology Center, Little Rock, AR, USA.
Frank SchwartzOhio University College of Osteopathic Medicine, Athens, OH, USA.
John B WelshMedtronic, Inc., Northridge, CA, USA john.b.welsh@medtronic.com.
Francine R KaufmanMedtronic, Inc., Northridge, CA, USA.
ASPIRE In-Home Study Group
Medtronic (United States) · USAtlanta Diabetes Associates · USAMCR Institute · USHadassah Medical Center · ILMills Peninsula Health Services · USOhio University · USUniversity of Colorado Denver · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypoglycemia varies between patients with type 1 diabetes and is the main obstacle to therapy intensification. We investigated known and potential risk factors for hypoglycemia in subjects with type 1 diabetes.

methodIn the ASPIRE In-Home study (NCT01497938), a randomized trial of the threshold suspend (TS) feature of sensor-augmented insulin pump (SAP) therapy, subjects' propensity to nocturnal hypoglycemia (NH) was established in a 2-week run-in phase and assessed in a 3-month study phase via continuous glucose monitoring. Categorical variables were tested for association with NH rates in both phases.

resultsElevated rates of NH were significantly associated with baseline A1C ≤7%, with bolus insulin deliveries unassisted by the bolus estimation calculator, and with assignment to the control group during the study phase.

conclusionsRoutine use of the TS feature and the bolus estimation calculator are strategies that may reduce the risk of NH.

Indexed as

Blood GlucoseBlood Glucose Self-MonitoringDiabetes Mellitus, Type 1FemaleHumansHypoglycemiaHypoglycemic AgentsInsulinInsulin Infusion SystemsMaleBlood GlucoseHypoglycemic AgentsInsulinASPIRE In-Homehypoglycemialow glucose suspendpredictionsensor-augmented pump therapythreshold suspend

Identifiers

PMID25986629
PMCPMC4667346
OpenAlexW2204586229

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.