Evidence map›Paper›PMID 25986609›Full record

ArticleMolecular and cellular biology2015

Male-Specific Cardiac Dysfunction in CTP:Phosphoethanolamine Cytidylyltransferase (Pcyt2)-Deficient Mice.

Poulami Basu, Faisal J Alibhai, Elena V Tsimakouridze, Ratnesh K Singh, Sabina Paglialunga, Graham P Holloway, Tami A Martino, Marica Bakovic

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Role of Stearoyl-CoA Desaturase 1 in Cardiovascular Physiology.International journal of molecular sciences · 2023
    Review
  7. Bilayer Forming Phospholipids as Targets for Cancer Therapy.International journal of molecular sciences · 2022
    Review
  8. Article
  9. Review
  10. Importance of lipids for upper motor neuron health and disease.Seminars in cell & developmental biology · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Lipid Use and Misuse by the Heart.Circulation research · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Poulami BasuDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Faisal J AlibhaiCardiovascular Research Group, Biomedical Sciences, University of Guelph, Guelph, ON, Canada.
Elena V TsimakouridzeCardiovascular Research Group, Biomedical Sciences, University of Guelph, Guelph, ON, Canada.
Ratnesh K SinghDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Sabina PaglialungaDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Graham P HollowayDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada.
Tami A MartinoCardiovascular Research Group, Biomedical Sciences, University of Guelph, Guelph, ON, Canada.
Marica BakovicDepartment of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada mbakovic@uoguelph.ca.
University of Guelph · CA

Funding

Canadian Institutes of Health Research MOP86448
6 · The paper itself

Abstract

Phosphatidylethanolamine (PE) is the most abundant inner membrane phospholipid. PE synthesis from ethanolamine and diacylglycerol is regulated primarily by CTP:phosphoethanolamine cytidylyltransferase (Pcyt2). Pcyt2(+/-) mice have reduced PE synthesis and, as a consequence, perturbed glucose and fatty acid metabolism, which gradually leads to the development of hyperlipidemia, obesity, and insulin resistance. Glucose and fatty acid uptake and the corresponding transporters Glut4 and Cd36 are similarly impaired in male and female Pcyt2(+/-) hearts. These mice also have similarly reduced phosphatidylinositol 3-kinase (PI3K)/Akt1 signaling and increased reactive oxygen species (ROS) production in the heart. However, only Pcyt2(+/-) males develop hypertension and cardiac hypertrophy. Pcyt2(+/-) males have upregulated heart AceI expression, heart phospholipids enriched in arachidonic acid and other n-6 polyunsaturated fatty acids, and dramatically increased ROS production in the aorta. In contrast, Pcyt2(+/-) females have unmodified heart phospholipids but have reduced heart triglyceride levels and altered expression of the structural genes Acta (low) and Myh7 (high). These changes together protect Pcyt2(+/-) females from cardiac dysfunction under conditions of reduced glucose and fatty acid uptake and heart insulin resistance. Our data identify Pcyt2 and membrane PE biogenesis as important determinants of gender-specific differences in cardiac lipids and heart function.

Indexed as

ActinsAnimalsAortaArachidonic AcidCardiomegalyCD36 AntigensFatty AcidsFemaleGlucoseGlucose Transporter Type 4HeartHyperlipidemiasHypertensionInsulin ResistanceLipid PeroxidationMaleActinsArachidonic AcidCD36 AntigensEthanolamine-phosphate cytidylyltransferaseFatty AcidsGlucoseGlucose Transporter Type 4Myh7 protein, mouseMyosin Heavy ChainsPeptidyl-Dipeptidase AphosphatidylethanolaminePhosphatidylethanolaminesPhosphatidylinositol 3-KinaseReactive Oxygen SpeciesRNA NucleotidyltransferasesSlc2a4 protein, mouse

Identifiers

PMID25986609
PMCPMC4524120
OpenAlexW1844194650

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.