Evidence map›Paper›PMID 25986583›Full record

ArticleGenome biology2015

Partial protein domains: evolutionary insights and bioinformatics challenges.

Lawrence A Kelley, Michael J E Sternberg

Abstract readComment
In one paragraph

Article in Genome biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. A computational model for GPCR-ligand interaction prediction.Journal of integrative bioinformatics · 2020
    Article
  5. Outer Membrane Protein A Conservation amongTropical medicine and infectious disease · 2018
    Article
  6. Complex evolutionary footprints revealed in an analysis of reused protein segments of diverse lengths.Proceedings of the National Academy of Sciences of the United States of America · 2017
    Article
  7. Classification and function of small open reading frames.Nature reviews. Molecular cell biology · 2017
    Article
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Lawrence A KelleyStructural Bioinformatics Group, Centre for Integrative Systems Biology and Bioinformatics, Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK. l.a.kelley@imperial.ac.uk.
Michael J E SternbergStructural Bioinformatics Group, Centre for Integrative Systems Biology and Bioinformatics, Department of Life Sciences, Imperial College London, London, SW7 2AZ, UK. m.sternberg@imperial.ac.uk.

Funding

Biotechnology and Biological Sciences Research Council BB/J019240/1Wellcome Trust WT/104955/Z/14/Z
6 · The paper itself

Abstract

Protein domains are generally thought to correspond to units of evolution. New research raises questions about how such domains are defined with bioinformatics tools and sheds light on how evolution has enabled partial domains to be viable.

Indexed as

Gene DeletionGenes, BacterialMolecular Sequence AnnotationProtein Structure, TertiarySequence AlignmentAnimalsBacterial ProteinsHumansLuciferasesOxidoreductasesProteinsBacterial ProteinsLuciferasesluxG protein, BacteriaOxidoreductasesProteins

Identifiers

PMID25986583
PMCPMC4436111

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.