Evidence map›Paper›PMID 25986558›Full record

ReviewCold Spring Harbor perspectives in biology2015

Recombination, Pairing, and Synapsis of Homologs during Meiosis.

Denise Zickler, Nancy Kleckner

Open access · hybridAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 490 papers.

0numbers the graph read from it
0cells of the map it votes in
490citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

490 citing papers in PubMed, 839 citations in OpenAlex.

  1. Article
  2. Controlling Meiotic Double-Strand Break Formation in Mice: A Web of Multivalent Protein-Protein Interactions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2026
    Review
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  8. BOULE is Essential for the Dynamic Disassembly of Heat Shock Granules in Male Germ Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  11. Review
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430 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Denise ZicklerInstitut de Génétique et Microbiologie, UMR 8621, Université Paris-Sud, 91405 Orsay, France.
Nancy KlecknerDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138.
Harvard University · USUniversité Paris-Sud · FR

Funding

MEIOTIC CHROMOSOME SYNAPSIS AND RECOMBINATION IN YEASTR01GM044794 · NIGMS · HARVARD UNIVERSITY · PI KLECKNER, NANCY E · 1990 to 2018
$13.8M
NIGMS NIH HHS GM-044794NIGMS NIH HHS R01 GM044794
6 · The paper itself

Abstract

Recombination is a prominent feature of meiosis in which it plays an important role in increasing genetic diversity during inheritance. Additionally, in most organisms, recombination also plays mechanical roles in chromosomal processes, most notably to mediate pairing of homologous chromosomes during prophase and, ultimately, to ensure regular segregation of homologous chromosomes when they separate at the first meiotic division. Recombinational interactions are also subject to important spatial patterning at both early and late stages. Recombination-mediated processes occur in physical and functional linkage with meiotic axial chromosome structure, with interplay in both directions, before, during, and after formation and dissolution of the synaptonemal complex (SC), a highly conserved meiosis-specific structure that links homolog axes along their lengths. These diverse processes also are integrated with recombination-independent interactions between homologous chromosomes, nonhomology-based chromosome couplings/clusterings, and diverse types of chromosome movement. This review provides an overview of these diverse processes and their interrelationships.

Indexed as

Chromosome PairingMeiosisRecombination, GeneticAnimalsChromosomesDNA Breaks, Double-StrandedHumansSynaptonemal Complex

Identifiers

PMID25986558
PMCPMC4448610
OpenAlexW2161758325

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.