ArticleBreast cancer research : BCR2015
Quantitative assessment of background parenchymal enhancement in breast MRI predicts response to risk-reducing salpingo-oophorectomy: preliminary evaluation in a cohort of BRCA1/2 mutation carriers.
Article in Breast cancer research : BCR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 40 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
40 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Characteristics and Pathologic Results of Foci on Breast Magnetic Resonance Imaging: A Systematic Review and Meta-Analysis.Journal of magnetic resonance imaging : JMRI · 2025Pooled it
- Breast cancer and background parenchymal enhancement at breast magnetic resonance imaging: a meta-analysis.BMC medical imaging · 2021Pooled it
- Evaluation of background parenchymal enhancement on breast MRI: a systematic review.The British journal of radiology · 2017Pooled it
- Impact of short-term low-dose tamoxifen on molecular breast imaging background parenchymal uptake: a pilot study.Breast cancer research : BCR · 2019Trial
- The Dose-Response Effects of Aerobic Exercise on Body Composition and Breast Tissue among Women at High Risk for Breast Cancer: A Randomized Trial.Cancer prevention research (Philadelphia, Pa.) · 2016Trial
- Automated calculation of background parenchymal enhancement as a biomarker of treatment responses and recurrence-free survival in breast cancer.Breast cancer research and treatment · 2026Article
- Racial differences in quantitative background parenchymal enhancement on breast magnetic resonance imaging.Cancer · 2025Article
- Impact of menopause and age on breast density and background parenchymal enhancement in dynamic contrast-enhanced magnetic resonance imaging.Journal of medical imaging (Bellingham, Wash.) · 2025Article
- Multiparametric MRI-based radiomic models for early prediction of response to neoadjuvant systemic therapy in triple-negative breast cancer.Scientific reports · 2024Article
- New Frontiers in Breast Cancer Imaging: The Rise of AI.Bioengineering (Basel, Switzerland) · 2024Review
- Assessment of Background Parenchymal Enhancement at Dynamic Contrast-enhanced MRI in Predicting Breast Cancer Recurrence Risk.Radiology · 2024Article
- Beyond Breast Density: Risk Measures for Breast Cancer in Multiple Imaging Modalities.Radiology · 2023Review
- Obesity and metabolic dysfunction correlate with background parenchymal enhancement in premenopausal women.Obesity (Silver Spring, Md.) · 2023Article
- Article
- Post-Processing Bias Field Inhomogeneity Correction for Assessing Background Parenchymal Enhancement on Breast MRI as a Quantitative Marker of Treatment Response.Tomography (Ann Arbor, Mich.) · 2022Article
- Clinical Artificial Intelligence Applications: Breast Imaging.Radiologic clinics of North America · 2021Review
- Quantitative Measures of Background Parenchymal Enhancement Predict Breast Cancer Risk.AJR. American journal of roentgenology · 2021Article
- Fully automatic quantification of fibroglandular tissue and background parenchymal enhancement with accurate implementation for axial and sagittal breast MRI protocols.Medical physics · 2021Article
- Harmonization of Quantitative Parenchymal Enhancement in TJournal of magnetic resonance imaging : JMRI · 2020Article
- Background parenchymal enhancement on breast MRI: A comprehensive review.Journal of magnetic resonance imaging : JMRI · 2020Review
Corrections and comments
- Correction · 2015-11-24Duplication of Data ·
- Erratum issued
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
introductionWe present a fully automated method for deriving quantitative measures of background parenchymal enhancement (BPE) from breast dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and perform a preliminary evaluation of these measures to assess the effect of risk-reducing salpingo-oophorectomy (RRSO) in a cohort of breast cancer susceptibility gene 1/2 (BRCA1/2) mutation carriers.
methodsBreast DCE-MRI data from 50 BRCA1/2 carriers were retrospectively analyzed in compliance with the Health Insurance Portability and Accountability Act and with institutional review board approval. Both the absolute (| |) and relative (%) measures of BPE and fibroglandular tissue (FGT) were computed from the MRI scans acquired before and after RRSO. These pre-RRSO and post-RRSO measures were compared using paired Student's t test. The area under the curve (AUC) of the receiver operating characteristic (ROC) was used to evaluate the performance of relative changes in the BPE and FGT measures in predicting breast cancer that developed in these women after the RRSO surgery.
resultsFor the 44 women who did not develop breast cancer after RRSO, the absolute volume of BPE and FGT had a significant decrease (P < 0.05) post-RRSO, whereas for the 6 women who developed breast cancer, there were no significant changes in these measures. Higher values in all BPE and FGT measures were also observed post-RRSO for the women who developed breast cancer, compared with women who did not. Relative changes in BPE percentage were most predictive of women who developed breast cancer after RRSO (P < 0.05), whereas combining BPE percentage and |FGT| yielded an AUC of 0.80, higher than BPE percentage (AUC = 0.78) or |FGT| (AUC = 0.66) alone (both P > 0.02).
conclusionsQuantitative measures of BPE and FGT are different before and after RRSO, and their relative changes are associated with prediction of developing breast cancer, potentially indicative of women who are more susceptible to develop breast cancer after RRSO in BRCA1/2 mutation carriers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.