Evidence map›Paper›PMID 25986383›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2015

Marrow adiposity assessed on transiliac crest biopsy samples correlates with noninvasive measurement of marrow adiposity by proton magnetic resonance spectroscopy ((1)H-MRS) at the spine but not the femur.

A Cohen, W Shen, D W Dempster, H Zhou, R R Recker, J M Lappe, A Kepley, M Kamanda-Kosseh, M Bucovsky, E M Stein and 2 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 38 citations in OpenAlex.

  1. Artificial gravity protects bone and prevents bone marrow adipose tissue accumulation in humans during 60 d of bed rest.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2025
    Trial
  2. Observational
  3. Article
  4. Article
  5. Bone marrow adipose tissue in metabolic health.Trends in endocrinology and metabolism: TEM · 2022
    Review
  6. In premenopausal women with idiopathic osteoporosis, lower bone formation rate is associated with higher body fat and higher IGF-1.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2022
    Article
  7. Obesity and Bone: A Complex Relationship.International journal of molecular sciences · 2021
    Review
  8. Fat and bone: the multiperspective analysis of a close relationship.Quantitative imaging in medicine and surgery · 2020
    Review
  9. Review
  10. Review
  11. Quantitative MRI and spectroscopy of bone marrow.Journal of magnetic resonance imaging : JMRI · 2018
    Review
  12. Article
  13. Reduced bone mass and preserved marrow adipose tissue in patients with inflammatory bowel diseases in long-term remission.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017
    Article
  14. Article
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

A CohenDepartment of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, New York, NY, 10032, USA. ac1044@columbia.edu.
W ShenDepartment of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, New York, NY, 10032, USA.
D W DempsterHelen Hayes Hospital, West Haverstraw, NY, USA.
H ZhouHelen Hayes Hospital, West Haverstraw, NY, USA.
R R ReckerCreighton University, Omaha, NE, USA.
J M LappeCreighton University, Omaha, NE, USA.
A KepleyDepartment of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, New York, NY, 10032, USA.
M Kamanda-KossehDepartment of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, New York, NY, 10032, USA.
M BucovskyDepartment of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, New York, NY, 10032, USA.
E M SteinDepartment of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, New York, NY, 10032, USA.
T L NickolasDepartment of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, New York, NY, 10032, USA.
E ShaneDepartment of Medicine, College of Physicians and Surgeons, Columbia University, PH8-864, 630 West 168th Street, New York, NY, 10032, USA.
Columbia University · USCreighton University · USHelen Hayes Hospital · US

Funding

RESEARCH TRAININGP30DK026687 · NIDDK · ST. LUKE'S-ROOSEVELT INST FOR HLTH SCIS · PI Anthony W Ferrante, DYMPNA GALLAGHER · 1986 to 2026
$33.0M
NIDDK NIH HHS P30 DK026687
6 · The paper itself

Abstract

unlabelledMeasurement of marrow fat (MF) is important to the study of bone fragility. We measured MF on iliac biopsies and by spine/hip magnetic resonance spectroscopy in the same subjects. Noninvasively assessed spine MF and histomorphometrically assessed MF correlated well. MF quantity and relationships with bone volume differed by measurement site.

introductionExcess marrow fat has been implicated in the pathogenesis of osteoporosis in several populations. In the bone marrow, adipocytes and osteoblasts share a common precursor and are reciprocally regulated. In addition, adipocytes may secrete toxic fatty acids and adipokines that adversely affect osteoblasts. Measurement of marrow fat is important to the study of mechanisms of bone fragility. Marrow fat can be quantified on bone biopsy samples by histomorphometry and noninvasively by proton magnetic resonance spectroscopy ((1)H-MRS). In this study, we evaluate relationships between marrow fat assessed using both methods in the same subjects for the first time.

methodsSixteen premenopausal women, nine with idiopathic osteoporosis and seven normal controls, had marrow fat measured at the iliac crest by bone biopsy and at the lumbar spine (L3) and proximal femur by (1)H-MRS.

resultsAt L3, fat fraction by (1)H-MRS correlated directly and significantly with marrow fat variables on iliac crest biopsies (r = 0.5-0.8). In contrast, there were no significant correlations between fat fraction at the femur and marrow fat on biopsies. Marrow fat quantity (%) was greater at the femur than at L3 and the iliac crest and correlated inversely with total hip and femoral neck BMD by DXA.

conclusionsIn summary, measurement of marrow fat in transiliac crest biopsies correlates with marrow fat at the spine but not the proximal femur by (1)H-MRS. There were site-specific differences in marrow fat quantity and in the relationships between marrow fat and bone volume.

Indexed as

AdipocytesAdipose TissueAdiposityAdolescentAdultBiopsyBone DensityBone MarrowBone Marrow ExaminationCase-Control StudiesFemaleFemurHumansIliumLumbar VertebraeMiddle Aged1H-MRSBone biopsyHistomorphometryMarrow fat

Identifiers

PMID25986383
PMCPMC5206911
OpenAlexW341064751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.