SynthesisClinical drug investigation2015
Comparison of glyburide with metformin in treating gestational diabetes mellitus: a systematic review and meta-analysis.
Synthesis in Clinical drug investigation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 6 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 6 syntheses or guidelines pooled it, 31 citations in OpenAlex.
- Circulating fibroblast growth factor 21 levels in gestational diabetes mellitus and preeclampsia: a systematic review and meta-analysis.BMC pregnancy and childbirth · 2025Pooled it
- Metformin versus glyburide in treatment and control of gestational diabetes mellitus: a systematic review with meta-analysis.Einstein (Sao Paulo, Brazil) · 2022 · on this mapPooled it
- Effectiveness of antidiabetic agents for treatment of gestational diabetes: A methodological quality assessment of meta-analyses and network meta-analysis.Journal of diabetes investigation · 2021Pooled it
- Comparative Efficacy and Safety of Metformin, Glyburide, and Insulin in Treating Gestational Diabetes Mellitus: A Meta-Analysis.Journal of diabetes research · 2019Pooled it
- Pooled it
- Oral anti-diabetic pharmacological therapies for the treatment of women with gestational diabetes.The Cochrane database of systematic reviews · 2017Pooled it
- Effects of Different Glucose-Lowering Measures on Maternal and Infant Outcomes in Pregnant Women with Gestational Diabetes: A Network Meta-analysis.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2021Article
- Gestational Diabetes: Overview with Emphasis on Medical Management.International journal of environmental research and public health · 2020Review
- Recent advances in the antepartum management of diabetes.F1000Research · 2019Review
- Prognostic factors for cesarean section outcome of pregnant women with gestational diabetes mellitus: a systematic review and meta-analysis.Diabetes, metabolic syndrome and obesity : targets and therapy · 2019Article
- Fibroblast growth factor-21 is a potential diagnostic factor for patients with gestational diabetes mellitus.Experimental and therapeutic medicine · 2018Article
- Metformin in the management of diabetes during pregnancy and lactation.Drugs in context · 2018Review
- Management of sulfonylurea-treated monogenic diabetes in pregnancy: implications of placental glibenclamide transfer.Diabetic medicine : a journal of the British Diabetic Association · 2017Review
- Article
- Metformin in gestational diabetes mellitus.The Indian journal of medical research · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectiveControversy has surrounded the treatment of gestational diabetes mellitus (GDM) for a long time. Although the use of both glyburide and metformin are recommended as an alternate to insulin if dietary therapy fails in GDM patients, it remains unclear whether both drugs are equally safe and efficacious. Therefore, in this review we compared the efficacy and safety of glyburide with metformin in treating GDM.
methodsA systematic review and meta-analysis of randomized controlled trials was conducted that compared the efficacy and safety of glyburide with metformin in GDM patients. Electronic databases were used to conduct the literature search for study identification along with a hand search of pertinent journals and conference proceedings. The effect measure used to present the results was risk ratio (RR) with 95% confidence interval (CI). A fixed-effects model was used to pool the data if no significant heterogeneity was reported and a random-effects model was used in the case of significant heterogeneity being reported for an outcome.
resultsThree studies involving 508 patients met the inclusion criteria of this review. A significant increase in the risk of the composite outcome, i.e., macrosomia and large for gestational age (LGA) births (RR 1.94; 95% CI 1.03-3.66, p = 0.04), was observed in the glyburide group, whereas a non-significant increase in the risk of neonatal hypoglycemia (RR 1.92; 95% CI 0.31-12.02) was also noticed. Results remained statistically non-significant for preterm births (RR 0.65; 95% CI 0.24-1.77), neonatal birth weight (mean difference (MD) 120.63 g; 95% CI -62.08 to 303.33), and cesarean section (RR 0.86; 95% CI 0.55-1.34). A significant decrease in fasting glucose levels (MD -2.40 mg/dL; 95% CI -4.60 to -0.21; p = 0.03) was noticed in glyburide group while the difference was non-significant for postprandial glucose levels (MD -0.84 mg/dL; 95% CI -4.03 to 2.35).
conclusionMetformin seems to be a superior choice to glyburide if oral antidiabetic drug therapy is to be initiated in GDM patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.