ArticleThe Journal of reproduction and development2015
Stress exposure during the preimplantation period affects blastocyst lineages and offspring development.
Article in The Journal of reproduction and development, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Does air pollution play a role in infertility?: a systematic review.Environmental health : a global access science source · 2017Pooled it
- Embryonic Mediators of Embryo-Uterus Communication, Implantation and Pregnancy.Molecular reproduction and development · 2026Review
- Sex-specific associations between psychological resilience and blastocyst quality.Reproduction & fertility · 2026Observational
- Maternal stress and the early embryonic microenvironment: investigating long-term cortisol effects on bovine oviductal epithelial cells using air-liquid interface culture.Journal of animal science and biotechnology · 2024Article
- Article
- Effects of non-aversive versus tail-lift handling on breeding productivity in a C57BL/6J mouse colony.PloS one · 2022Article
- Glucocorticoid Exposure of Preimplantation Embryos Increases Offspring Anxiety-Like Behavior by Upregulating miR-211-5pFrontiers in cell and developmental biology · 2022Article
- Effect of vitrification on global gene expression dynamics of bovine elongating embryos.Reproduction, fertility, and development · 2021Article
- Review
- Corticosterone induced apoptosis of mouse oviduct epithelial cells independent of the TNF-α system.The Journal of reproduction and development · 2021Article
- Review of psychological stress on oocyte and early embryonic development in female mice.Reproductive biology and endocrinology : RB&E · 2020Review
- Alteration in the time and/or mode of delivery differentially modulates early development in mice.Molecular brain · 2020Article
- Does Maternal Stress Affect the Early Embryonic Microenvironment? Impact of Long-Term Cortisol Stimulation on the Oviduct Epithelium.International journal of molecular sciences · 2020Article
- Prenatal Maternal Stress Causes Preterm Birth and Affects Neonatal Adaptive Immunity in Mice.Frontiers in immunology · 2020Article
- Effect of Predator Stress on the Reproductive Performance of Female Mice After Nonsurgical Embryo Transfer.Journal of the American Association for Laboratory Animal Science : JAALAS · 2019Article
- Hypoxic Stress Forces Irreversible Differentiation of a Majority of Mouse Trophoblast Stem Cells Despite FGF4.Biology of reproduction · 2016Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We found retardation of preimplantation embryo growth after exposure to maternal restraint stress during the preimplantation period in our previous study. In the present study, we evaluated the impact of preimplantation maternal restraint stress on the distribution of inner cell mass (ICM) and trophectoderm (TE) cells in mouse blastocysts, and its possible effect on physiological development of offspring. We exposed spontaneously ovulating female mice to restraint stress for 30 min three times a day during the preimplantation period, and this treatment caused a significant increase in blood serum corticosterone concentration. Microscopic evaluation of embryos showed that restraint stress significantly decreased cell counts per blastocyst. Comparing the effect of restraint stress on the two blastocyst cell lineages, we found that the reduction in TE cells was more substantial than the reduction in ICM cells, which resulted in an increased ICM/TE ratio in blastocysts isolated from stressed dams compared with controls. Restraint stress reduced the number of implantation sites in uteri, significantly delayed eye opening in delivered mice, and altered their behavior in terms of two parameters (scratching on the base of an open field test apparatus, time spent in central zone) as well. Moreover, prenatally stressed offspring had significantly lower body weights and in 5-week old females delivered from stressed dams, fat deposits were significantly lower. Our results indicate that exposure to stress during very early pregnancy can have a negative impact on embryonic development with consequences reaching into postnatal life.
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