ArticleNature materials2015
Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates.
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In one paragraph
Article in Nature materials, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 369 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
369citing papers in PubMed, 1 pooled it
62.8field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
369 citing papers in PubMed, 1 synthesis or guideline pooled it, 865 citations in OpenAlex.
- Large Animal Studies to Reduce the Foreign Body Reaction in Brain-Computer Interfaces: A Systematic Review.Biosensors · 2021Pooled it
- Mechano-immunomodulatory biomaterials: From immune mechanosensing to translational design.Bioactive materials · 2026Review
- Minimally invasive bioelectronic implants.Nature materials · 2026Review
- Immune-epigenetic convergence in biomaterial-guided tissue regeneration.Materials today. Bio · 2026Article
- Engineering the Immune-Stromal Microenvironment: A Design Framework for Regenerative Biomaterials.Cells · 2026Review
- In Vivo Continuous Biosensing: Design Considerations and Emerging Technologies.Small (Weinheim an der Bergstrasse, Germany) · 2026Review
- Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio-Interactive Materials.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Biomimetic zona pellucida-encapsulated islets for sustained glycaemic control in immunocompetent mice.Nature biomedical engineering · 2026Article
- Nanoparticle-Enabled Biomaterials for Controlled Drug Delivery in Implantable and Wearable Devices.International journal of molecular sciences · 2026Review
- Localized immunomodulation with cytokine-producing cells to mitigate foreign body responses in rodents and a nonhuman primate.Science advances · 2026Article
- Hydrogels: current biomedical applications and future directions.Molecular biomedicine · 2026Review
- Biomaterial-Driven Modulation of Macrophage Polarization in an Experimental Environment of Implant-Associated Infection Mediated byJournal of functional biomaterials · 2026Review
- A modular hydrogel system with independent control of bioadhesion, fibrosis, and stiffness.Science advances · 2026Article
- Physical and Mechanical Characterisation of 3D-Bioprinted Hydrogels for Dental Applications: A Scoping Review.Gels (Basel, Switzerland) · 2026Review
- Apolipoprotein E knockout attenuates vascular graft fibrosis by reducing profibrotic macrophage formation through low-density lipoprotein receptor related protein 1.Bioactive materials · 2026Article
- Spatially controlled Islet delivery into a bioengineered vascular Niche improves subcutaneous transplantation.Biomedical microdevices · 2026Article
- Engineering the oxygen microenvironment for pancreatic islet transplants.NPJ Regenerative medicine · 2026Review
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- A synthetic angiotensin II/ACE2-based hormone shunt controlling experimental hypertension.Nature communications · 2026Article
309 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
30 authors at 6 institutions in 2 countries.
Omid Veiseh1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [3] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Joshua C Doloff1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Minglin Ma1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA [3] Section on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA.
Arturo J Vegas1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Hok Hei Tam1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Andrew R Bader1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Jie Li1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Erin Langan1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Jeffrey WyckoffDavid H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA.
Whitney S LooDepartment of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Siddharth Jhunjhunwala1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Alan Chiu1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Sean Siebert1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Katherine Tang1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Jennifer Hollister-LockSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA.
Stephanie Aresta-Dasilva1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Matthew BochenekDivision of Transplantation, Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Chicago, Illinois 60612, USA.
Joshua Mendoza-EliasDivision of Transplantation, Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Chicago, Illinois 60612, USA.
Yong WangDivision of Transplantation, Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Chicago, Illinois 60612, USA.
Merigeng QiDivision of Transplantation, Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Chicago, Illinois 60612, USA.
Danya M Lavin1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Michael Chen1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Nimit Dholakia1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Raj Thakrar1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA.
Igor LacíkDepartment for Biomaterials Research, Polymer Institute of the Slovak Academy of Sciences, Dubravska cesta 9, 845 41 Bratislava, Slovakia.
Gordon C WeirSection on Islet Cell and Regenerative Biology, Research Division, Joslin Diabetes Center, One Joslin Place, Boston, Massachusetts 02215, USA.
Jose OberholzerDivision of Transplantation, Department of Surgery, University of Illinois at Chicago, 840 South Wood Street, Chicago, Illinois 60612, USA.
Dale L GreinerProgram in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA.
Robert Langer1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [3] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA [4] Division of Health Science Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [5] Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [6] Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Daniel G Anderson1] David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, 500 Main Street, Cambridge, Massachusetts 02139, USA [2] Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [3] Department of Anesthesiology, Boston Children's Hospital, 300 Longwood Ave, Boston, Massachusetts 02115, USA [4] Division of Health Science Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [5] Institute for Medical Engineering and Science, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA [6] Harvard-MIT Division of Health Science and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.
Massachusetts Institute of Technology · USUniversity of Illinois Chicago · USBoston Children's Hospital · USJoslin Diabetes Center · USSlovak Academy of Sciences · SKUniversity of Massachusetts Chan Medical School · US
Funding
VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI MATTHEW G. VANDER HEIDEN · 1985 to 2026
$93.9MSPECIAL ASSAY COREP30DK036836 · NIDDK · JOSLIN DIABETES CENTER · PI JEAN E. SCHAFFER · 1986 to 2026
$50.5MTREATMENT OF CANCER WITH siRNA DELVIERED BY NANOPARTICLESU54CA119349 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI WEISSLEDER, MD, PHD, RALPH · 2005 to 2009
$20.5MThe Development of Clinical Grade, Targeted Magnetic NanoparticlesU54CA151884 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2010 to 2014
$11.3MPHOTOPOLYMERIZATION FOR NONINVASIVE CARTILAGE TISSUER01DE013023 · NIDCR · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 1998 to 2019
$6.8MCONTROLLED RELEASE OF MACROMOLECULESR01EB000244 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL, TRAVERSO, CARLO GIOVANNI · 2002 to 2021
$6.1MControlled Release of MacromoleculesR37EB000244 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2008 to 2017
$3.9MUltrasound Polymeric Drug DeliveryR01EB000351 · NIBIB · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI LANGER, ROBERT SAMUEL · 2002 to 2013
$3.0MBeta Cell Specific Microfluidic Perifusion and Imaging for Islet Potency TestingR01DK091526 · NIDDK · UNIVERSITY OF ILLINOIS AT CHICAGO · PI OBERHOLZER, JOSE · 2011 to 2015
$1.7MNCI NIH HHS CA151884NCI NIH HHS P30 CA014051NCI NIH HHS P30-CA14051NCI NIH HHS U54 CA119349NCI NIH HHS U54 CA151884NIBIB NIH HHS EB000244NIBIB NIH HHS EB000351NIBIB NIH HHS R01 EB000244NIBIB NIH HHS R01 EB000351NIBIB NIH HHS R37 EB000244NIDCR NIH HHS DE013023NIDCR NIH HHS R01 DE013023NIDDK NIH HHS R01 DK091526NIDDK NIH HHS R01DK091526
Abstract
The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of the geometry of implanted materials on their biocompatibility in vivo. In rodent and non-human primate animal models, implanted spheres 1.5 mm and above in diameter across a broad spectrum of materials, including hydrogels, ceramics, metals and plastics, significantly abrogated foreign body reactions and fibrosis when compared with smaller spheres. We also show that for encapsulated rat pancreatic islet cells transplanted into streptozotocin-treated diabetic C57BL/6 mice, islets prepared in 1.5-mm alginate capsules were able to restore blood-glucose control for up to 180 days, a period more than five times longer than for transplanted grafts encapsulated within conventionally sized 0.5-mm alginate capsules. Our findings suggest that the in vivo biocompatibility of biomedical devices can be significantly improved simply by tuning their spherical dimensions.
Indexed as
AnimalsForeign-Body ReactionMiceMice, Inbred C57BLPrimates
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