ArticleJournal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society2015
Superoxide generation explains common features of optic neuropathies associated with cecocentral scotomas.
Article in Journal of neuro-ophthalmology : the official journal of the North American Neuro-Ophthalmology Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Impact of Inner Retinal Layer Thinning on Visual Function in OPA1 Autosomal Dominant Optic Atrophy and Associations With Age and Genetic Variant Class.Investigative ophthalmology & visual science · 2026Article
- Maculopapillary Bundle Degeneration in Optic Neuropathies.Current neurology and neuroscience reports · 2024Review
- Mitochondrial DNA variants in a cohort from Argentina with suspected Leber's hereditary optic neuropathy (LHON).PloS one · 2023Article
- The Relative Preservation of the Central Retinal Layers in Leber Hereditary Optic Neuropathy.Journal of clinical medicine · 2022Article
- Neuroprotective Effect of Azithromycin Following Induction of Optic Nerve Crush in Wild Type and Immunodeficient Mice.International journal of molecular sciences · 2022Article
- The Genetics of Ethambutol-Induced Optic Neuropathy: A Narrative Review.Neuro-ophthalmology (Aeolus Press) · 2022Review
- A Case of Presumed Bonsai-induced Severe Toxic Optic Neuropathy.Neuro-ophthalmology (Aeolus Press) · 2022Article
- Pathophysiology of Conversion to Symptomatic Leber Hereditary Optic Neuropathy and Therapeutic Implications: a Review.Current neurology and neuroscience reports · 2020Review
- Propagation and Selectivity of Axonal Loss in Leber Hereditary Optic Neuropathy.Scientific reports · 2019Article
- Cobalamin-Associated Superoxide Scavenging in Neuronal Cells Is a Potential Mechanism for Vitamin BThe American journal of pathology · 2018Article
- Evaluating the therapeutic potential of idebenone and related quinone analogues in Leber hereditary optic neuropathy.Mitochondrion · 2017Article
- The pattern of retinal ganglion cell dysfunction in Leber hereditary optic neuropathy.Mitochondrion · 2017Article
- A neurodegenerative perspective on mitochondrial optic neuropathies.Acta neuropathologica · 2016Review
- Trauma-Associated Leber Hereditary Optic Neuropathy.Neuro-ophthalmology (Aeolus Press) · 2016Article
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Abstract
I have presented above a hypothesis that ties together several disparate optic neuropathies, all characterized by a similar clinical presentation. The hypothesis is predicated on the formation of intracellular superoxide within RGCs as a common pathological pathway for the type of cell death that occurs. The anatomical predisposition of the papillomacular bundle to have elevated superoxide levels is tied to the size of the fibers involved, a hypothesis that also implicates the crossing fibers of the chiasm. Much of this work is speculative and is an interpretation of several experimental studies that have been performed to date. Hopefully, this hypothesis will be developed further, and its validity tested in both experimental models and, ultimately, in humans.
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