ArticleBiomarkers in medicine2015
Association of estrogen measurements in serum and urine of premenopausal women.
Article in Biomarkers in medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed.
- Low-dose aspirin in reproductive health: effects on menstrual cycle characteristics.Fertility and sterility · 2020Trial
- Sex Hormones in Women With Elevated Breast Cancer Risk Undergoing Weight Loss.Western journal of nursing research · 2019Trial
- Microextraction of steroidal hormones from urine samples using natural deep eutectic solvents: insights into chemical interactions using molecular dynamics simulations.Analytical and bioanalytical chemistry · 2025Article
- Association between urine and serum estradiol levels in in vitro fertilization cycles.Scientific reports · 2022Article
- Associations of established breast cancer risk factors with urinary estrogens in postmenopausal women.Cancer causes & control : CCC · 2022Article
- The NIMH Intramural Longitudinal Study of the Endocrine and Neurobiological Events Accompanying Puberty: Protocol and rationale for methods and measures.NeuroImage · 2021Article
- LC-HRMS of derivatized urinary estrogens and estrogen metabolites in postmenopausal women.Journal of chromatography. B, Analytical technologies in the biomedical and life sciences · 2020Article
- Effects of Dietary Phytoestrogens on Hormones throughout a Human Lifespan: A Review.Nutrients · 2020Review
- Comparability of serum, plasma, and urinary estrogen and estrogen metabolite measurements by sex and menopausal status.Cancer causes & control : CCC · 2019Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
aimsWe evaluated conjugated and unconjugated urinary estrogen metabolites as surrogate biomarkers for serum levels of unconjugated E1 and E2 in premenopausal women. MATERIALS &
methodsRepeated blood and urine samples were analyzed for estrogens and their metabolites using radioimmunoassays and liquid chromatography/mass spectrometry.
resultsThe strongest correlation (r = 0.39) was observed between serum E1 and urinary E1 and E2. The correlations of urinary E2 (r = 0.35), E1 (r = 0.29), all E2 metabolites (r = 0.30), all E1 metabolites (r = 0.23) and total estrogens (r = 0.26) with serum E2 were only moderate although statistically significant. All correlations were substantially stronger for Whites than Asians.
conclusionUrinary E2 emerged as the best predictor for serum E1 and E2, but the large intra-subject variability in urinary estrogen levels limits its use as a biomarker.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.