ArticleScientific reports2015
In vitro properties of designed antimicrobial peptides that exhibit potent antipneumococcal activity and produces synergism in combination with penicillin.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Combinatorial prediction of therapeutic perturbations using causally inspired neural networks.Nature biomedical engineering · 2026Article
- Rational designing and synthesizing an antimicrobial peptide from bovine milk casein and evaluating its biological properties.Amino acids · 2025Article
- Antimicrobial Peptide Reduces Cytotoxicity and Inflammation in Canine Epidermal Keratinocyte Progenitor Cells Induced byVeterinary sciences · 2024Article
- Functional Characterization, Antimicrobial Effects, and Potential Antibacterial Mechanisms ofMarine drugs · 2022Article
- Steroid-Functionalized Imidazolium Salts with an Extended Spectrum of Antifungal and Antibacterial Activity.International journal of molecular sciences · 2021Article
- RM12 similar to substance P from tachykinin of freshwater murrel Channa striatus influence intracellular ROS in vitro fish erythrocytes and developmental toxicity and antioxidant enzymes in vivo zebrafish embryo.Fish physiology and biochemistry · 2021Article
- Advances in the Study of Structural Modification and Biological Activities of Anoplin.Frontiers in chemistry · 2020Review
- Article
- Structural insights into the combinatorial effects of antimicrobial peptides reveal a role of aromatic-aromatic interactions in antibacterial synergism.The Journal of biological chemistry · 2019Article
- Effect of Amino Acid Substitutions on Biological Activity of Antimicrobial Peptide: Design, Recombinant Production, and Biological Activity.Iranian journal of pharmaceutical research : IJPR · 2019Article
- Hydrophobic interactions modulate antimicrobial peptoid selectivity towards anionic lipid membranes.Biochimica et biophysica acta. Biomembranes · 2018Article
- Evaluation of cytotoxicity features of antimicrobial peptides with potential to control bacterial diseases of citrus.PloS one · 2018Article
- Therapeutic ultrasound potentiates the anti-nociceptive and anti-inflammatory effects of curcumin to postoperative pain via Sirt1/NF-κB signaling pathway.American journal of translational research · 2018Article
- Intracellular Targeting Mechanisms by Antimicrobial Peptides.Antimicrobial agents and chemotherapy · 2017Review
- The Antimicrobial Peptides P-113Du and P-113Tri Function against Candida albicans.Antimicrobial agents and chemotherapy · 2016Article
- Transcriptome analysis of Streptococcus pneumoniae treated with the designed antimicrobial peptides, DM3.Scientific reports · 2016Article
- Structure and Bioactivity of a Modified Peptide Derived from the LPS-Binding Domain of an Anti-Lipopolysaccharide Factor (ALF) of Shrimp.Marine drugs · 2016Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Antimicrobial peptides (AMPs) represent a promising class of novel antimicrobial agents owing to their potent antimicrobial activity. In this study, two lead peptides from unrelated classes of AMPs were systematically hybridized into a series of five hybrid peptides (DM1-DM5) with conserved N- and C-termini. This approach allows sequence bridging of two highly dissimilar AMPs and enables sequence-activity relationship be detailed down to single amino acid level. Presence of specific amino acids and physicochemical properties were used to describe the antipneumococcal activity of these hybrids. Results obtained suggested that cell wall and/or membrane targeting could be the principal mechanism exerted by the hybrids leading to microbial cell killing. Moreover, the pneumocidal rate was greater than penicillin (PEN). Combination treatment with both DMs and PEN produced synergism. The hybrids were also broad spectrum against multiple common clinical bacteria. Sequence analysis showed that presence of specific residues has a major role in affecting the antimicrobial and cell toxicity of the hybrids than physicochemical properties. Future studies should continue to investigate the mechanisms of actions, in vivo therapeutic potential, and improve rational peptide design based on the current strategy.
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Registered trials
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