Evidence map›Paper›PMID 25985046›Full record

Trial reportPsychotherapy (Chicago, Ill.)2015

Predictors of longitudinal outcomes after unstable response to acute-phase cognitive therapy for major depressive disorder.

Jeffrey R Vittengl, Lee Anna Clark, Michael E Thase, Robin B Jarrett

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in Psychotherapy (Chicago, Ill.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Trial
  4. Are Patients with Childhood Onset of Insomnia and Depression More Difficult to Treat Than Are Those with Adult Onsets of These Disorders? A Report from the TRIAD Study.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2017
    Trial
  5. Trial
  6. Trial
  7. Trial
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jeffrey R VittenglDepartment of Psychology.
Lee Anna ClarkDepartment of Psychology, University of Notre Dame.
Michael E ThaseDepartment of Psychiatry, Perelman School of Medicine, University of Pennsylvania.
Robin B JarrettDepartment of Psychiatry, The University of Texas Southwestern Medical Center.

Funding

PROPHYLACTIC COGNITIVE THERAPY FOR DEPRESSIONR01MH058397 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI JARRETT, ROBIN B · 2000 to 2011
$4.1M
PROPHYLACTIC COGNITIVE THERAPY FOR DEPRESSIONR01MH058356 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI THASE, MICHAEL E · 2000 to 2010
$3.5M
Are Cognitive Therapy's Antidepressant Effects Durable?R01MH069619 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI JARRETT, ROBIN B · 2004 to 2009
$1.7M
Are Cognitive Therapy's Antidepressant Effects Durable?R01MH069618 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FRIEDMAN, EDWARD S. · 2004 to 2008
$1.5M
Cognitive Therapy for High Risk &Refractory DepressionK24MH001571 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI JARRETT, ROBIN B · 2005 to 2009
$625k
NIMH NIH HHS K24 MH001571NIMH NIH HHS R01 MH058356NIMH NIH HHS R01 MH058397NIMH NIH HHS R01 MH069618NIMH NIH HHS R01 MH069619NIMH NIH HHS R01 MH58356NIMH NIH HHS R01 MH58397NIMH NIH HHS R01MH69618NIMH NIH HHS R01 MH69619
6 · The paper itself

Abstract

After patients with major depressive disorder (MDD) respond to acute-phase cognitive therapy (CT), continuation-phase treatments may be applied to improve long-term outcomes. We clarified which CT responders experience remission, recovery, relapse, and recurrence by testing baseline demographic, clinical, and personality variables. The sample of CT responders at higher risk of relapse (N = 241) was randomized to 8 months of continuation-phase CT, double-blinded fluoxetine, or pill placebo, and followed 24 months (Jarrett & Thase, 2010). Patients with lower positive emotionality and behavioral activation at the end of acute-phase CT showed increased risk for relapse/recurrence of MDD. In addition, patients with lower positive emotionality and behavioral activation, as well as higher residual depression (including emotional, cognitive, and social facets), showed decreased probability of remission (≥6 continuous weeks of minimal or absent symptoms) after acute-phase CT. Finally, patients with greater residual depression, as well as younger age and earlier MDD onset, showed decreased probability of recovery (≥35 continuous weeks of minimal or absent symptoms) after acute-phase CT. Moderator analyses did not reveal differential prediction across the continuation phase treatment arms. These results may help clinicians gauge the prognoses and need for continuation treatment among MDD patients who respond to acute-phase CT.

Indexed as

Cognitive Behavioral TherapyAdultAge FactorsAntidepressive Agents, Second-GenerationChronic DiseaseDouble-Blind MethodFemaleFluoxetineFollow-Up StudiesHumansLongitudinal StudiesMajor Depressive DisorderMaleRecurrenceRiskTreatment OutcomeAntidepressive Agents, Second-GenerationFluoxetine

Identifiers

PMID25985046
PMCPMC4438278

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.