Evidence map›Paper›PMID 25984990›Full record

ReviewMarine drugs2015

Emerging concepts promising new horizons for marine biodiscovery and synthetic biology.

F Jerry Reen, José A Gutiérrez-Barranquero, Alan D W Dobson, Claire Adams, Fergal O'Gara

Abstract readReview
In one paragraph

Review in Marine drugs, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Efflux, Signaling and Warfare in a Polymicrobial World.Antibiotics (Basel, Switzerland) · 2023
    Review
  9. Article
  10. Review
  11. Review
  12. Saudi journal of biological sciences · 2022
    Article
  13. Article
  14. Article
  15. Seasonal Variation in Antimicrobial Activity of Crude Extracts ofInternational journal of microbiology · 2021
    Article
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

F Jerry ReenBIOMERIT Research Centre, School of Microbiology, University College Cork-National University of Ireland, Cork, Ireland. j.reen@ucc.ie.
José A Gutiérrez-BarranqueroBIOMERIT Research Centre, School of Microbiology, University College Cork-National University of Ireland, Cork, Ireland.
Alan D W DobsonSchool of Microbiology, University College Cork-National University of Ireland, Cork, Ireland. a.dobson@ucc.ie.
Claire AdamsBIOMERIT Research Centre, School of Microbiology, University College Cork-National University of Ireland, Cork, Ireland. c.adams@ucc.ie.
Fergal O'GaraBIOMERIT Research Centre, School of Microbiology, University College Cork-National University of Ireland, Cork, Ireland. f.ogara@ucc.ie.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vast oceans of the world, which comprise a huge variety of unique ecosystems, are emerging as a rich and relatively untapped source of novel bioactive compounds with invaluable biotechnological and pharmaceutical potential. Evidence accumulated over the last decade has revealed that the diversity of marine microorganisms is enormous with many thousands of bacterial species detected that were previously unknown. Associated with this diversity is the production of diverse repertoires of bioactive compounds ranging from peptides and enzymes to more complex secondary metabolites that have significant bioactivity and thus the potential to be exploited for innovative biotechnology. Here we review the discovery and functional potential of marine bioactive peptides such as lantibiotics, nanoantibiotics and peptidomimetics, which have received particular attention in recent years in light of their broad spectrum of bioactivity. The significance of marine peptides in cell-to-cell communication and how this may be exploited in the discovery of novel bioactivity is also explored. Finally, with the recent advances in bioinformatics and synthetic biology, it is becoming clear that the integration of these disciplines with genetic and biochemical characterization of the novel marine peptides, offers the most potential in the development of the next generation of societal solutions.

Indexed as

AnimalsAquatic OrganismsBiological ProductsEcosystemHumansMarine BiologyPeptidesSynthetic BiologyBiological ProductsPeptideslantibioticsmarine bioactivesmimeticsmotif/domainpeptidesquorum quenchingquorum sensingsignaling molecules

Identifiers

PMID25984990
PMCPMC4446613

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.