SynthesisPloS one2015
Heterogeneity of prognostic studies of 24-hour blood pressure variability: systematic review and meta-analysis.
Synthesis in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Association Between Blood Pressure Variability With Dementia and Cognitive Impairment: A Systematic Review and Meta-Analysis.Hypertension (Dallas, Tex. : 1979) · 2021Pooled it
- Association Between Blood Pressure Variability and Cerebral Small-Vessel Disease: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2020Pooled it
- 24-Hour Blood Pressure Variability Assessed by Average Real Variability: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2017Pooled it
- Blood pressure variability and cardiovascular disease: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2016Pooled it
- Cardiovascular and metabolic effects of a mandibular advancement device and continuous positive airway pressure in moderate obstructive sleep apnea: a randomized controlled trial.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Trial
- Blood pressure variability: a review.Journal of hypertension · 2025Review
- Long-term blood pressure patterns in midlife and dementia in later life: Findings from the Framingham Heart Study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Circadian aspects of mortality in hospitalized patients: A retrospective observation from a large cohort.Nursing open · 2023Observational
- Cross-sectional associations between short and mid-term blood pressure variability, cognition, and vascular stiffness in older adults.Cerebral circulation - cognition and behavior · 2023Article
- Time-Restricted Eating in Metabolic Syndrome-Focus on Blood Pressure Outcomes.Current hypertension reports · 2022Review
- E-Selectin Is Associated with Daytime and 24-Hour Diastolic Blood Pressure Variability in Type 2 Diabetes.Biomedicines · 2022Article
- Circadian Blood Pressure Variations Computed From 1.7 Million Measurements in an Acute Hospital Setting.American journal of hypertension · 2019Article
- The Adaptive Value and Clinical Significance of Allostatic Blood Pressure Variation.Current hypertension reviews · 2019Review
- Time-Dependent Hypotensive Effect of Aspirin in Mice.Arteriosclerosis, thrombosis, and vascular biology · 2018Article
- The association between blood pressure variability (BPV) with dementia and cognitive function: a systematic review and meta-analysis protocol.Systematic reviews · 2018Article
- Role of the circadian system in cardiovascular disease.The Journal of clinical investigation · 2018Review
- Blood-pressure variability in patients with obstructive sleep apnea: current perspectives.Nature and science of sleep · 2018Review
- Target-Mediated Drug Disposition Pharmacokinetic-Pharmacodynamic Model of Bosentan and Endothelin-1.Clinical pharmacokinetics · 2017Article
- Short-term blood pressure variability and long-term blood pressure variability: which one is a reliable predictor for recurrent stroke.Journal of human hypertension · 2017Article
- Exploring diurnal variation using piecewise linear splines: an example using blood pressure.Emerging themes in epidemiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In addition to mean blood pressure, blood pressure variability is hypothesized to have important prognostic value in evaluating cardiovascular risk. We aimed to assess the prognostic value of blood pressure variability within 24 hours. Using MEDLINE, EMBASE and Cochrane Library to April 2013, we conducted a systematic review of prospective studies of adults, with at least one year follow-up and any day, night or 24-hour blood pressure variability measure as a predictor of one or more of the following outcomes: all-cause mortality, cardiovascular mortality, all cardiovascular events, stroke and coronary heart disease. We examined how blood pressure variability is defined and how its prognostic use is reported. We analysed relative risks adjusted for covariates including the appropriate mean blood pressure and considered the potential for meta-analysis. Our analysis of methods included 24 studies and analysis of predictions included 16 studies. There were 36 different measures of blood pressure variability and 13 definitions of night- and day-time periods. Median follow-up was 5.5 years (interquartile range 4.2-7.0). Comparing measures of dispersion, coefficient of variation was less well researched than standard deviation. Night dipping based on percentage change was the most researched measure and the only measure for which data could be meaningfully pooled. Night dipping or lower night-time blood pressure was associated with lower risk of cardiovascular events. The interpretation and use in clinical practice of 24-hour blood pressure variability, as an important prognostic indicator of cardiovascular events, is hampered by insufficient evidence and divergent methodologies. We recommend greater standardisation of methods.
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