ArticlePloS one2015
The Association between Mycobacterium Tuberculosis Genotype and Drug Resistance in Peru.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 34 citations in OpenAlex.
- Detection of drug resistance mutations and spoligotype mapping in Mycobacterium tuberculosis using deeplex sequencing, including novel and uncharacterized spoligotypes.Archives of microbiology · 2026Article
- Detection of drug resistance mutations and spoligotype mapping in Mycobacterium tuberculosis using deeplex sequencing, including novel and uncharacterized spoligotypes.Archives of microbiology · 2026Article
- Dissecting rifampicin heteroresistance inJournal of medical microbiology · 2025Article
- Molecular epidemiology ofJournal of clinical tuberculosis and other mycobacterial diseases · 2024Review
- Detection of a historic reservoir of bedaquiline/clofazimine resistance-associated variants in Mycobacterium tuberculosis.Genome medicine · 2024Article
- Prevalence, drug resistance, and genotypic diversity of the RDFrontiers in public health · 2024Article
- Advantages of analysing both pairwise SNV-distance and differing SNVs betweenMicrobial genomics · 2023Article
- Evolution ofFrontiers in cellular and infection microbiology · 2022Review
- A case report of transmission and disease caused by Mycobacterium caprae and Mycobacterium bovis in Lima, Peru.BMC infectious diseases · 2021Article
- Dysglycemia is associated with Mycobacterium tuberculosis lineages in tuberculosis patients of North Lima-Peru.PloS one · 2021Article
- Circulation ofPathogens and global health · 2019Review
- Review
- One Health approach in the prevention and control of mycobacterial infections in Tanzania: lessons learnt and future perspectives.One health outlook · 2019Review
- Whole genomic sequencing as a tool for diagnosis of drug and multidrug-resistance tuberculosis in an endemic region in Mexico.PloS one · 2019Article
- Investigating spillover of multidrug-resistant tuberculosis from a prison: a spatial and molecular epidemiological analysis.BMC medicine · 2018Article
- Genetic diversity of drug and multidrug-resistant Mycobacterium tuberculosis circulating in Veracruz, Mexico.PloS one · 2018Article
- The impact of drug resistance on the risk of tuberculosis infection and disease in child household contacts: a cross sectional study.BMC infectious diseases · 2017Article
- Convergent evolution and topologically disruptive polymorphisms among multidrug-resistant tuberculosis in Peru.PloS one · 2017Article
- High rate of drug resistance among tuberculous meningitis cases in Shaanxi province, China.Scientific reports · 2016Article
- Analysis of Mycobacterium tuberculosis Genotypic Lineage Distribution in Chile and Neighboring Countries.PloS one · 2016Article
Corrections and comments
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Authors and funding
18 authors at 8 institutions in 4 countries.
Funding
Abstract
backgroundThe comparison of Mycobacterium tuberculosis bacterial genotypes with phenotypic, demographic, geospatial and clinical data improves our understanding of how strain lineage influences the development of drug-resistance and the spread of tuberculosis.
methodsTo investigate the association of Mycobacterium tuberculosis bacterial genotype with drug-resistance. Drug susceptibility testing together with genotyping using both 15-loci MIRU-typing and spoligotyping, was performed on 2,139 culture positive isolates, each from a different patient in Lima, Peru. Demographic, geospatial and socio-economic data were collected using questionnaires, global positioning equipment and the latest national census.
resultsThe Latin American Mediterranean (LAM) clade (OR 2.4, p<0.001) was significantly associated with drug-resistance and alone accounted for more than half of all drug resistance in the region. Previously treated patients, prisoners and genetically clustered cases were also significantly associated with drug-resistance (OR's 2.5, 2.4 and 1.8, p<0.001, p<0.05, p<0.001 respectively).
conclusionsTuberculosis disease caused by the LAM clade was more likely to be drug resistant independent of important clinical, genetic and socio-economic confounding factors. Explanations for this include; the preferential co-evolution of LAM strains in a Latin American population, a LAM strain bacterial genetic background that favors drug-resistance or the "founder effect" from pre-existing LAM strains disproportionately exposed to drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.