SynthesisInternational journal of molecular sciences2015
Ultrasound assessment of carotid plaque echogenicity response to statin therapy: a systematic review and meta-analysis.
Synthesis in International journal of molecular sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Efficacy of acupuncture in patients with carotid atherosclerosis: a randomized controlled clinical trial.BMC complementary medicine and therapies · 2024Trial
- Deep learning-based early prediction of carotid plaque response to lipid-lowering therapy using longitudinal multimodal ultrasound imaging.Insights into imaging · 2026Article
- Echogenicity of carotid plaques as a predictor of regression following lipid-lowering therapy.Thrombosis journal · 2025Article
- Efficient Gene Editing for Heart Disease via ELIP-Based CRISPR Delivery System.Pharmaceutics · 2024Article
- Heterogeneous Carotid Plaque Predicts Cardiovascular Events after Percutaneous Coronary Intervention.Journal of atherosclerosis and thrombosis · 2023Article
- MR Imaging of Carotid Artery Atherosclerosis: Updated Evidence on High-Risk Plaque Features and Emerging Trends.AJNR. American journal of neuroradiology · 2023Review
- Advances in Noninvasive Carotid Wall Imaging with Ultrasound: A Narrative Review.Journal of clinical medicine · 2022Review
- Plaque characteristics and biomarkers predicting regression and progression of carotid atherosclerosis.Cell reports. Medicine · 2022Article
- Triglyceride-Glucose Index Is Related to Carotid Plaque and Its Stability in Nondiabetic Adults: A Cross-Sectional Study.Frontiers in neurology · 2022Article
- Roadmap Consensus on Carotid Artery Plaque Imaging and Impact on Therapy Strategies and Guidelines: An International, Multispecialty, Expert Review and Position Statement.AJNR. American journal of neuroradiology · 2021Article
- Carotid Atherosclerosis, Ultrasound and Lipoproteins.Biomedicines · 2021Review
- Doppler Ultrasound Monitoring of Echogenicity in Asymptomatic Subcritical Carotid Stenosis and Assessment of Response to Oral Supplementation of Vitamin K2 (PLAK2 Randomized Controlled Trial).Diagnostics (Basel, Switzerland) · 2021Article
- Inflammation of carotid plaques and risk of cerebrovascular events.Annals of translational medicine · 2020Review
- Association Between Carotid Ultrasonography Findings and Colorectal Adenoma in Asymptomatic Adults.Digestive diseases and sciences · 2020Article
- Influence of Ultrasound System and Gain on Grayscale Median Values.Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine · 2019Article
- Stabilization of symptomatic carotid atherosclerotic plaques by statins: a clinico-pathological analysis.Heart and vessels · 2018Article
- What We Have Learned from the Recent Meta-analyses on Diagnostic Methods for Atherosclerotic Plaque Regression.Current atherosclerosis reports · 2018Review
- Pleiotropic effects of statins in the perioperative setting.Annals of cardiac anaesthesia · 2017Review
- Atherosclerotic Calcification Detection: A Comparative Study of Carotid Ultrasound and Cone Beam CT.International journal of molecular sciences · 2015Article
- Effects of statins on plaque characteristics of intracranial atherosclerosis assessed by high-resolution magnetic resonance imaging.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate in a systematic review and meta-analysis model the effect of statin therapy on carotid plaque echogenicity assessed by ultrasound.
methodsWe have systematically searched electronic databases (PubMed, MEDLINE, EMBASE and Cochrane Center Register) up to April, 2015, for studies evaluating the effect of statins on plaque echogenicity. Two researchers independently determined the eligibility of studies evaluating the effect of statin therapy on carotid plaque echogenicity that used ultrasound and grey scale median (GSM) or integrated back scatter (IBS).
resultsNine out of 580 identified studies including 566 patients' carotid artery data were meta-analyzed for a mean follow up of 7.2 months. A consistent increase in the echogenicity of carotid artery plaques, after statin therapy, was reported. Pooled weighted mean difference % (WMD) on plaque echogenicity after statin therapy was 29% (95% CI 22%-36%), p<0.001, I2=92.1%. In a meta-regression analysis using % mean changes of LDL, HDL and hsCRP as moderators, it was shown that the effects of statins on plaque echogenicity were related to changes in hsCRP, but not to LDL and HDL changes from the baseline. The effect of statins on the plaque was progressive; it showed significance after the first month of treatment, and the echogenicity continued to increase in the following six and 12 months.
conclusionsStatin therapy is associated with a favorable increase of carotid plaque echogenicity. This effect seems to be dependent on the period of treatment and hsCRP change from the baseline, independent of changes in LDL and HDL.
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