Evidence map›Paper›PMID 25984569›Full record

ArticleACS biomaterials science & engineering2015

Nanomanufacturing of Tobacco Mosaic Virus-Based Spherical Biomaterials Using a Continuous Flow Method.

Michael A Bruckman, Allen VanMeter, Nicole F Steinmetz

Open access · greenAbstract read
In one paragraph

Article in ACS biomaterials science & engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 39 citations in OpenAlex.

  1. Article
  2. Artificial viruses: A nanotechnology based approach.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024
    Review
  3. Article
  4. Article
  5. Bioconjugation Strategies for Tobacco Mild Green Mosaic Virus.Chembiochem : a European journal of chemical biology · 2022
    Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. Physical, chemical, and synthetic virology: Reprogramming viruses as controllable nanodevices.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2019
    Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Tobacco mosaic virus-based protein nanoparticles and nanorods for chemotherapy delivery targeting breast cancer.Journal of controlled release : official journal of the Controlled Release Society · 2016
    Article
  17. Article
  18. Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Michael A BruckmanDepartment of Biomedical Engineering, Department of Radiology, Department of Materials Science and Engineering, and Department of Macromolecular Engineering, Case Western Reserve University Schools of Medicine and Engineering , 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
Allen VanMeterDepartment of Biomedical Engineering, Department of Radiology, Department of Materials Science and Engineering, and Department of Macromolecular Engineering, Case Western Reserve University Schools of Medicine and Engineering , 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
Nicole F SteinmetzDepartment of Biomedical Engineering, Department of Radiology, Department of Materials Science and Engineering, and Department of Macromolecular Engineering, Case Western Reserve University Schools of Medicine and Engineering , 10900 Euclid Avenue, Cleveland, Ohio 44106, United States.
University School · US

Funding

Cardiovascular Research Training Program (CRTP)T32HL105338 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI JAIN, MUKESH KUMAR · 2010 to 2014
$1.8M
NHLBI NIH HHS T32 HL105338
6 · The paper itself

Abstract

Nanomanufacturing of nanoparticles is critical for potential translation and commercialization. Continuous flow devices can alleviate this need through unceasing production of nanoparticles. Here we demonstrate the scaled-up production of spherical nanoparticles functionalized with biomedical cargos from the rod-shaped plant virus tobacco mosaic virus (TMV) using a mesofluidic, continued flow method. Production yields were increased 30-fold comparing the mesofluidic device versus batch methods. Finally, we produced MRI contrast agents of select sizes, with per particle relaxivity reaching 979,218 mM

Indexed as

mesofluidic deviceMRI contrast agentsnanomanufacturingnanoparticle shapetobacco mosaic virus

Identifiers

PMID25984569
PMCPMC4426350
OpenAlexW2327283371

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.