Evidence map›Paper›PMID 25984555›Full record

ArticleOptica

Ultrasonic-heating-encoded photoacoustic tomography with virtually augmented detection view.

Lidai Wang, Guo Li, Jun Xia, Lihong V Wang

Open access · goldAbstract read
In one paragraph

Article in Optica. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Spherical Array System for High-Precision Transcranial Ultrasound Stimulation and Optoacoustic Imaging in Rodents.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Article
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  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lidai WangOptical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130-4899, USA.
Guo LiOptical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130-4899, USA.
Jun XiaOptical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130-4899, USA.
Lihong V WangOptical Imaging Laboratory, Department of Biomedical Engineering, Washington University in St. Louis Campus Box 1097, One Brookings Drive, St. Louis, Missouri 63130-4899, USA.
Washington University in St. Louis · US

Funding

PHOTON TUNNELING: SHEDDING NEW LIGHT ON BIOMEDICINEDP1EB016986 · NIBIB · WASHINGTON UNIVERSITY · PI WANG, LIHONG · 2012 to 2016
$3.8M
IN VIVO IMAGING OF SINGLE CIRCULATING CELLSR01CA186567 · NCI · WASHINGTON UNIVERSITY · PI WANG, LIHONG · 2013 to 2017
$3.6M
PHOTOACOUSTIC MICROSCOPY OF NEOVASCULARIZATION IN RENAL CANCER GROWTH AND THERAPYR01CA159959 · NCI · WASHINGTON UNIVERSITY · PI ARBEIT, JEFFREY MICHAEL · 2011 to 2015
$2.9M
WHOLE-BODY SMALL-ANIMAL PHOTOACOUSTIC-ULTRASONIC COMPUTED TOMOGRAPHYR01EB016963 · NIBIB · WASHINGTON UNIVERSITY · PI ANASTASIO, MARK A · 2013 to 2016
$2.4M
Development of Thermoacoustic Tomography Brain ImagingR01EB010049 · NIBIB · WASHINGTON UNIVERSITY · PI ANASTASIO, MARK A · 2010 to 2013
$1.6M
HIGH-FREQUENCY ULTRASONIC AND PHOTOACOUSTIC IMAGING SYSTEMS10RR026922 · NCRR · WASHINGTON UNIVERSITY · PI WANG, LIHONG · 2011 to 2011
$599k
NCI NIH HHS R01 CA159959NCI NIH HHS R01 CA186567NCRR NIH HHS S10 RR026922NIBIB NIH HHS DP1 EB016986NIBIB NIH HHS R01 EB010049NIBIB NIH HHS R01 EB016963
6 · The paper itself

Abstract

Photoacoustic (PA) imaging of arbitrarily-shaped or oriented objects may miss important features because PA waves propagate normal to structure boundaries and may miss the acoustic detectors when the detection view has a limited angular range. To overcome this long-standing problem, we present an ultrasonic thermal encoding approach that is universally applicable. We exploit the temperature dependence of the Grueneisen parameter and encode a confined [[What does confined mean here?]] voxel using heat generated by a focused ultrasonic transducer. The PA amplitude from the encoded voxel is increased while those from the neighboring voxels are unchanged. Consequently, the amplitude-increased PA waves propagate in all directions due to the round cross-section of the encoded region and thus can be received at any viewing angle on the cross-sectional plane [[Please check throughout the manuscript for similar places.]]. We built a mathematical model for the thermally encoded PA tomography, performed a numerical simulation, and experimentally validated the ultrasonic thermal encoding efficiency. As a proof of concept, we demonstrate full-view in vivo vascular imaging and compare it to the original linear-array PA tomography system, showing dramatically enhanced imaging of arbitrarily oriented blood vessels. Since ultrasonic heating can be focused deeply, this method can be applied to deep tissue imaging and is promising for full-view imaging of other features of biomedical interest, such as tumor margins.

Identifiers

PMID25984555
PMCPMC4429303
OpenAlexW1973866134

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.