Evidence map›Paper›PMID 25984509›Full record

ArticleFrontiers in pediatrics2015

Development of a Custom-Designed, Pan Genomic DNA Microarray to Characterize Strain-Level Diversity among Cronobacter spp.

Ben Davies Tall, Jayanthi Gangiredla, Gopal R Gopinath, Qiongqiong Yan, Hannah R Chase, Boram Lee, Seongeun Hwang, Larisa Trach, Eunbi Park, YeonJoo Yoo and 13 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
3.4field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 22 citations in OpenAlex.

  1. Characterization ofMicroorganisms · 2022
    Article
  2. Analysis of the Molecular Diversity AmongFrontiers in microbiology · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 6 institutions in 5 countries.

Ben Davies TallCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
Jayanthi GangiredlaCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
Gopal R GopinathCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
Qiongqiong YanUCD Centre for Food Safety, School of Public Health, Physiotherapy and Population Science, University College Dublin , Dublin , Ireland ; WHO Collaborating Centre for Cronobacter , Dublin , Ireland.
Hannah R ChaseCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
Boram LeeCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
Seongeun HwangCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
Larisa TrachCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
Eunbi ParkCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
YeonJoo YooCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
TaeJung ChungCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
Scott A JacksonCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
Isha R PatelCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
Venugopal SathyamoorthyCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
Monica Pava-RipollCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , College Park, MD , USA.
Michael L KotewiczCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
Laurenda CarterCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
Carol IversenCollege of Life Sciences, University of Dundee , Dundee , UK.
Franco PagottoFood Directorate, Bureau of Microbial Hazards/Health Canada , Ottawa, ON , Canada.
Roger StephanInstitute for Food Safety and Hygiene, University of Zurich , Zurich , Switzerland.
Angelika LehnerInstitute for Food Safety and Hygiene, University of Zurich , Zurich , Switzerland.
Séamus FanningUCD Centre for Food Safety, School of Public Health, Physiotherapy and Population Science, University College Dublin , Dublin , Ireland ; WHO Collaborating Centre for Cronobacter , Dublin , Ireland.
Christopher J GrimCenter of Food Safety and Applied Nutrition, U. S. Food and Drug Administration , Laurel, MD , USA.
United States Food and Drug Administration · USCenter for Food Safety and Applied Nutrition · USUniversity College Dublin · IEUniversity of Zurich · CHHealth Canada · CAUniversity of Dundee · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cronobacter species cause infections in all age groups; however neonates are at highest risk and remain the most susceptible age group for life-threatening invasive disease. The genus contains seven species:Cronobacter sakazakii, Cronobacter malonaticus, Cronobacter turicensis, Cronobacter muytjensii, Cronobacter dublinensis, Cronobacter universalis, and Cronobacter condimenti. Despite an abundance of published genomes of these species, genomics-based epidemiology of the genus is not well established. The gene content of a diverse group of 126 unique Cronobacter and taxonomically related isolates was determined using a pan genomic-based DNA microarray as a genotyping tool and as a means to identify outbreak isolates for food safety, environmental, and clinical surveillance purposes. The microarray constitutes 19,287 independent genes representing 15 Cronobacter genomes and 18 plasmids and 2,371 virulence factor genes of phylogenetically related Gram-negative bacteria. The Cronobacter microarray was able to distinguish the seven Cronobacter species from one another and from non-Cronobacter species; and within each species, strains grouped into distinct clusters based on their genomic diversity. These results also support the phylogenic divergence of the genus and clearly highlight the genomic diversity among each member of the genus. The current study establishes a powerful platform for further genomics research of this diverse genus, an important prerequisite toward the development of future countermeasures against this foodborne pathogen in the food safety and clinical arenas.

Indexed as

Cronobactergenomic diversitymicroarraypan genomicphylogenic divergence

Identifiers

PMID25984509
PMCPMC4415424
OpenAlexW2026504187

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.