ArticleCardiovascular diagnosis and therapy2015
Salt in the wound: (18)F-fluoride positron emission tomography for identification of vulnerable coronary plaques.
Article in Cardiovascular diagnosis and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Simultaneous assessment of microcalcifications and morphological criteria of vulnerability in carotid artery plaque using hybridJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- Cardiovascular disease risk and pathogenesis in systemic lupus erythematosus.Seminars in immunopathology · 2022Review
- Alavi-Carlsen Calcification Score (ACCS): A Simple Measure of Global Cardiac Atherosclerosis Burden.Diagnostics (Basel, Switzerland) · 2021Article
- Vulnerable plaque imaging usingThe British journal of radiology · 2020Review
- Atherosclerosis imaging withEuropean journal of nuclear medicine and molecular imaging · 2020Review
- Coronary Atherosclerosis Imaging.Diagnostics (Basel, Switzerland) · 2020Review
- Imaging aortic wall inflammation.Trends in cardiovascular medicine · 2019Review
- Three-Hour Delayed Imaging Improves Assessment of CoronaryJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2019Article
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- Feasibility of CoronaryCirculation. Cardiovascular imaging · 2018Article
- A novel fluorescein-bisphosphonate based diagnostic tool for the detection of hydroxyapatite in both cell and tissue models.Scientific reports · 2018Article
- Monocyte and Macrophage Dynamics in the Cardiovascular System: JACC Macrophage in CVD Series (Part 3).Journal of the American College of Cardiology · 2018Review
- Assessment of atherosclerotic plaque calcification using F18-NaF PET-CT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018 · on this mapArticle
- Noninvasive Coronary Plaque Imaging.Journal of atherosclerosis and thrombosis · 2018Review
- Safety Evaluation and Imaging Properties of Gadolinium-Based Nanoparticles in nonhuman primates.Scientific reports · 2016Article
- Update on cardiovascular disease in lupus.Current opinion in rheumatology · 2016Review
- Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques.Nature materials · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Ischaemic vascular events occur in relation to an underlying vulnerable plaque. The pathological hallmarks of high-risk plaques are well described and include inflammation and microcalcification. To date, non-invasive imaging modalities have lacked the spatial resolution to detect these processes with the necessary precision to facilitate clinical utility. Positron emission tomography (PET) using targeted radiopharmaceuticals affords a highly sensitive tool for identifying features of interest and has been in use for several decades in oncological practice. Recent developments have created hybrid scanning platforms which add the detailed spatial resolution of computed tomography (CT) and, for the first time, made imaging of individual coronary plaques feasible. In this study we compared the utility of PET-CT using (18)F-fluoride and (18)F-fluorodeoxglucose ((18)F-FDG) to detect high-risk or ruptured atherosclerotic plaques in vivo. (18)F-fluoride localized to culprit and vulnerable plaques as determined by a combination of invasive imaging and histological tissue examination. In contradistinction, (18)F-FDG analysis was compromised by non-specific myocardial uptake that obscured the coronary arteries. We discuss the findings of this study, the limitations of the current approach of vulnerable plaque assessment and some on-going developments in cardiovascular imaging with (18)F-fluoride.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.