ArticleSurgical neurology international2015
Autologous fibrin sealant (Vivostat(®)) in the neurosurgical practice: Part I: Intracranial surgical procedure.
Article in Surgical neurology international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 45 citations in OpenAlex.
- A comparative analysis of early postoperative outcomes of autologous pericranium versus high-density polypropylene in cranial duraplasty in a tertiary care center in Central India.Chinese neurosurgical journal · 2026Article
- Acute brain swelling due to intraoperative supratentorial subdural hematoma during microvascular decompression: a case report.Frontiers in surgery · 2025Article
- The chemistry of snake venom and its medicinal potential.Nature reviews. Chemistry · 2022Review
- Pitfalls regarding the neurosurgical management of traumatic supra and infratentorial extradural haematomas.Neurosurgical review · 2021Article
- A prognostic scoring system for operated acute epidural hematoma based on gray-white matter ratio.Medicine · 2021Article
- Autologous fibrin sealant application in cardiac surgery - a single-centre observational study.Kardiochirurgia i torakochirurgia polska = Polish journal of cardio-thoracic surgery · 2021Article
- Pre-operative imaging and post-operative appearance of standard paediatric neurosurgical approaches: a training guide for neuroradiologists.Translational pediatrics · 2021Review
- Skull Base Csf- Leak Closure with Autologous Fibrin Sealant.Iranian journal of otorhinolaryngology · 2021Article
- Integrity of dural closure after autologous platelet rich fibrin augmentation: an in vitro study.Acta neurochirurgica · 2020Article
- From Animal Poisons and Venoms to Medicines: Achievements, Challenges and Perspectives in Drug Discovery.Frontiers in pharmacology · 2020Review
- Neurosurgical Care of Nonpowder Firearm Injuries: A Narrative Review of the Literature.Emergency medicine international · 2019Review
- New Hope in Brain Glioma Surgery: The Role of Intraoperative Ultrasound. A Review.Brain sciences · 2018Review
- Brain Mapping as Helpful Tool in Brain Glioma Surgical Treatment-Toward the "Perfect Surgery"?Brain sciences · 2018Article
- Clinical and radiological features of Forestier's disease presenting with dysphagia.Surgical neurology international · 2018Article
- Never say never again: A bone graft infection due to a hornet sting, thirty-nine years after cranioplasty.Surgical neurology international · 2017Article
- Fluorescein for resection of high-grade gliomas: A safety study control in a single center and review of the literature.Surgical neurology international · 2017Article
- Article
- Aulogous fibrin sealant (Vivostat(®)) in the neurosurgical practice: Part II: Vertebro-spinal procedures.Surgical neurology international · 2016Article
- Surgical nuances on the treatment of giant dumbbell cervical spine schwannomas: description of a challenging case and review of the literature.Spinal cord series and cases · 2016Article
- Intradural Intramedullary Mixed Type Hemangioma: Optimizing the Surgical Management through Intraoperative Neurophysiological Monitoring.Case reports in surgery · 2015Article
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Authors and funding
8 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHemorrhages, cerebrospinal fluid (CSF) fistula and infections are the most challenging postoperative complications in Neurosurgery. In this study, we report our preliminary results using a fully autologous fibrin sealant agent, the Vivostat(®) system, in achieving hemostasis and CSF leakage repair during cranio-cerebral procedures.
methodsFrom January 2012 to March 2014, 77 patients were studied prospectively and data were collected and analyzed. Autologous fibrin sealant, taken from patient's blood, was prepared with the Vivostat(®) system and applied on the resection bed or above the dura mater to achieve hemostasis and dural sealing. The surgical technique, time to bleeding control and associated complications were recorded.
resultsA total of 79 neurosurgical procedures have been performed on 77 patients. In the majority of cases (98%) the same autologous fibrin glue provided rapid hemostasis and dural sealing. No patient developed allergic reactions or systemic complications in association with its application. There were no cases of cerebral hematoma, swelling, infection, or epileptic seizures after surgery whether in the immediate or in late period follow-up.
conclusionsIn this preliminary study, the easy and direct application of autologous fibrin sealant agent helped in controlling cerebral bleeding and in providing prompt and efficient dural sealing with resolution of CSF leaks. Although the use of autologous fibrin glue seems to be safe, easy, and effective, further investigations are strongly recommended to quantify real advantages and potential limitations.
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