ArticleTherapeutic advances in chronic disease2015
The prevalence of vascular calcification in patients with end-stage renal disease on hemodialysis: a cross-sectional observational study.
Article in Therapeutic advances in chronic disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Risk factors for coronary artery calcification in Chinese patients undergoing maintenance hemodialysis: a meta-analysis.International urology and nephrology · 2025Pooled it
- Pooled it
- Prevalence of abdominal artery calcification in dialysis patients with end-stage renal disease: a systematic review and meta-analysis.International urology and nephrology · 2017Pooled it
- High-Flux Hemodialysis Benefits Hemodialysis Patients by Reducing Serum FGF-23 Levels and Reducing Vascular Calcification.Medical science monitor : international medical journal of experimental and clinical research · 2015Trial
- Clinical characteristics, treatment, and outcomes in CIED-related vs. left-sided infective endocarditis: a nationwide study from the NIDUS registry.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2026Article
- Characteristics and prognostic values of abdominal aortic branches calcification in hemodialysis patients.Renal failure · 2025Article
- Understanding Vascular Calcification in Chronic Kidney Disease: Pathogenesis and Therapeutic Implications.International journal of molecular sciences · 2024Review
- Construction of aRenal failure · 2024Article
- Review
- Novel Biomarkers in Evaluating Cardiac Function in Patients on Hemodialysis-A Pilot Prospective Observational Cohort Study.Diagnostics (Basel, Switzerland) · 2024Article
- Stents migration into right atrium from severely calcified superior vena cava in a hemodialysis patient.Heliyon · 2024Article
- Abdominal aortic calcification score can predict all-cause and cardiovascular mortality in maintenance hemodialysis patients.Renal failure · 2023Article
- CircHIPK3 relieves vascular calcification via mediating SIRT1/PGC-1α/MFN2 pathway by interacting with FUS.BMC cardiovascular disorders · 2023Article
- Article
- Progression of Vascular Calcification and Clinical Outcomes in Patients Receiving Maintenance Dialysis.JAMA network open · 2023Article
- Cardiovascular Calcification Heterogeneity in Chronic Kidney Disease.Circulation research · 2023Review
- Role of the gut microbiota and their metabolites in hemodialysis patients.International journal of medical sciences · 2023Article
- Eye Lesions in Patients After One Year of Kidney Transplantation.Clinical ophthalmology (Auckland, N.Z.) · 2023Article
- Calcification detection on upper extremity arteries: a comparison of ultrasonic and X-ray methods.PeerJ · 2023Article
- Prognosis and risk factors for cardiac valve calcification in Chinese end-stage kidney disease patients on combination therapy with hemodialysis and hemodiafiltration.Renal failure · 2022Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis multicenter international cross-sectional observational study characterized vascular and valvular calcification burden and correlations with pulse pressure, diabetes, hypertension, and cardiovascular diseases in prevalent hemodialysis patients.
methodsWe enrolled 275 consecutive adults with end-stage renal disease on maintenance hemodialysis for ⩾3 months. Coprimary endpoints were prevalences of: (1) echocardiographic calcification in mitral valve, aortic valve or mitral annulus; (2) aortoiliac tree vascular calcifications by plain lateral lumbar X-ray. Correlations among calcification sites and with demographics and comorbidities were determined. Pulse pressures were determined.
resultsSubjects' mean ± standard deviation (SD) age was 56 ± 15.9 years; mean (SD) dialysis duration was 4.5 ± 4.3 years. Overall, 100% of echocardiographically imaged patients (n = 243) had calcification in aortic valve, mitral valve, or mitral annulus; 77.8% of X-rayed patients (n = 248) had abdominal aortic calcification. Radiographic abdominal aortic calcification score correlated significantly with calcification of aortic valve (p < 0.0001) and mitral annulus (p = 0.0001) but not mitral valve. Aortic valve, mitral valve, and mitral annulus calcification correlated significantly among themselves (p < 0.0001). Moderate/severe aortic valve calcification was significantly more prevalent in patients aged ⩾65 years than <65 years, men than women, and Whites than African Americans. Pulse pressure correlated significantly with vascular calcification score (p = 0.0049) but not with valvular calcification at any site.
conclusionsVascular and valvular calcification are highly prevalent in the hemodialysis population. Peripheral vascular calcification correlates significantly with elevated pulse pressure and can be assessed easily using lateral lumbar X-ray. Further studies investigating the interaction between pulse pressure and development or progression of vascular calcification are of interest.
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