Evidence map›Paper›PMID 25984248›Full record

ArticleCardiovascular engineering and technology2015

Human Cardiac Function Simulator for the Optimal Design of a Novel Annuloplasty Ring with a Sub-valvular Element for Correction of Ischemic Mitral Regurgitation.

Brian Baillargeon, Ivan Costa, Joseph R Leach, Lik Chuan Lee, Martin Genet, Arnaud Toutain, Jonathan F Wenk, Manuel K Rausch, Nuno Rebelo, Gabriel Acevedo-Bolton and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cardiovascular engineering and technology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

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  17. A partition of unity approach to fluid mechanics and fluid-structure interaction.Computer methods in applied mechanics and engineering · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Brian BaillargeonDassault Systèmes Simulia Corporation, Fremont, CA USA.
Ivan CostaGraduate Program in Material Science (PPG-CIMA), Faculty UnB Planaltina, University of Brasilia, Brasília, Brazil.
Joseph R LeachDepartment of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, USA.
Lik Chuan LeeDepartment of Mechanical Engineering, Michigan State University, East Lansing, MI USA.
Martin GenetInstitute for Biomedical Engineering, University and ETH Zürich, Zurich, Switzerland ; Department of Surgery, University of California at San Francisco, San Francisco, USA.
Arnaud ToutainDepartment of Surgery, University of California at San Francisco, San Francisco, USA.
Jonathan F WenkDepartment of Mechanical Engineering, University of Kentucky, Lexington, KY USA.
Manuel K RauschDepartments of Mechanical Engineering, Bioengineering and Cardiothoracic Surgery, Stanford University, Stanford, CA USA.
Nuno RebeloDassault Systèmes Simulia Corporation, Fremont, CA USA.
Gabriel Acevedo-BoltonDepartment of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, USA ; Department of Surgery, University of California at San Francisco, San Francisco, USA.
Ellen KuhlDepartments of Mechanical Engineering, Bioengineering and Cardiothoracic Surgery, Stanford University, Stanford, CA USA.
Jose L NaviaDepartment of Cardiovascular and Thoracic Surgery, Cleveland Clinic, Cleveland, OH USA.
Julius M GuccioneDepartment of Surgery, University of California at San Francisco, San Francisco, USA ; Division of Adult Cardiothoracic Surgery, Department of Surgery, School of Medicine, Mount Zion Harold Brunn Institute for Cardiovascular Research, UCSF, 1657 Scott St., Room 219, San Francisco, CA 94143 USA.

Funding

Physics-based Simulation of Biological Structures(RMI)U54GM072970 · NIGMS · STANFORD UNIVERSITY · PI PANDE, VIJAY S · 2004 to 2013
$33.5M
VISUALIZATION TOOLS FOR AUTOMATED MOLECULAR MICROSCOPYP41RR008605 · NCRR · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MCCULLOCH, ANDREW D. · 1994 to 2011
$28.1M
Multi-Scale Laws of Myocardial Growth and RemodelingU01HL119578 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUCCIONE, JULIUS MATTEO, KASSAB, GHASSAN S · 2014 to 2018
$3.8M
VIRTUAL TOOLS FOR CARDIAC VENTRICULAR REMODELING SURGERYR01HL077921 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GUCCIONE, JULIUS MATTEO · 2006 to 2015
$3.4M
Minimally Invasive Ventricular Polymeric Injection for Treatment of Heart FailureR01HL118627 · NHLBI · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI GUCCIONE, JULIUS MATTEO, KASSAB, GHASSAN S · 2013 to 2016
$3.0M
Time-resolved MR methods for analysis of contrast and flow velocity in aneurysmsK25NS058573 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ACEVEDO-BOLTON, GABRIEL ALEJANDRO · 2008 to 2012
$704k
NCRR NIH HHS P41 RR008605NHLBI NIH HHS R01 HL077921NHLBI NIH HHS R01-HL-077921NHLBI NIH HHS R01 HL118627NHLBI NIH HHS R01-HL-118627NHLBI NIH HHS U01 HL119578NHLBI NIH HHS U01-HL-119578NIGMS NIH HHS U54 GM072970NINDS NIH HHS K25 NS058573NINDS NIH HHS K25-NS058573-05
6 · The paper itself

Abstract

Ischemic mitral regurgitation is associated with substantial risk of death. We sought to: (1) detail significant recent improvements to the Dassault Systèmes human cardiac function simulator (HCFS); (2) use the HCFS to simulate normal cardiac function as well as pathologic function in the setting of posterior left ventricular (LV) papillary muscle infarction; and (3) debut our novel device for correction of ischemic mitral regurgitation. We synthesized two recent studies of human myocardial mechanics. The first study presented the robust and integrative finite element HCFS. Its primary limitation was its poor diastolic performance with an LV ejection fraction below 20% caused by overly stiff ex vivo porcine tissue parameters. The second study derived improved diastolic myocardial material parameters using in vivo MRI data from five normal human subjects. We combined these models to simulate ischemic mitral regurgitation by computationally infarcting an LV region including the posterior papillary muscle. Contact between our novel device and the mitral valve apparatus was simulated using Dassault Systèmes SIMULIA software. Incorporating improved cardiac geometry and diastolic myocardial material properties in the HCFS resulted in a realistic LV ejection fraction of 55%. Simulating infarction of posterior papillary muscle caused regurgitant mitral valve mechanics. Implementation of our novel device corrected valve dysfunction. Improvements in the current study to the HCFS permit increasingly accurate study of myocardial mechanics. The first application of this simulator to abnormal human cardiac function suggests that our novel annuloplasty ring with a sub-valvular element will correct ischemic mitral regurgitation.

Indexed as

Models, AnatomicModels, CardiovascularAnimalsComputer SimulationHumansMaleMitral ValveMitral Valve AnnuloplastyMitral Valve InsufficiencyMyocardial InfarctionSoftwareSwineTricuspid ValveVentricular Dysfunction, LeftVentricular RemodelingFinite element methodIschemic mitral regurgitationMitral annuloplastyMyocardial infarctionRealistic simulationVentricular function

Identifiers

PMID25984248
PMCPMC4427655

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.