ArticleInternational journal of endocrinology2015
High Doses of Caffeine during the Peripubertal Period in the Rat Impair the Growth and Function of the Testis.
Article in International journal of endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 30 citations in OpenAlex.
- Concomitant caffeine exposure and chronic sleep deprivation impair male sexual performance and fecundity via monoaminergic and hypothalamic-pituitary-adrenal/gonadal axis dysregulation in rats.BMC research notes · 2026Article
- Associations of caffeine and caffeine metabolites with sex hormones among 6-19-year-old children and adolescents.Scientific reports · 2025Article
- Associations of urinary caffeine metabolites with sex hormones: comparison of three statistical models.Frontiers in nutrition · 2024Article
- Effect of caffeine on genes expressions of developing retinas in the chick model.Anatomy & cell biology · 2022Article
- The association between caffeine intake and testosterone: NHANES 2013-2014.Nutrition journal · 2022Article
- The Effects of High Peripubertal Caffeine Exposure on the Adrenal Gland in Immature Male and Female Rats.Nutrients · 2019Article
- The perinatal effects of maternal caffeine intake on fetal and neonatal brain levels of testosterone, estradiol, and dihydrotestosterone in rats.Naunyn-Schmiedeberg's archives of pharmacology · 2017Article
- The Effects of Caffeine on the Long Bones and Testes in Immature and Young Adult Rats.Toxicological research · 2017Article
- Dose- and time-related effects of caffeine on the testis in immature male rats.Experimental animals · 2017Article
- Psychostimulant-Induced Testicular Toxicity in Mice: Evidence of Cocaine and Caffeine Effects on the Local Dopaminergic System.PloS one · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal caffeine exposure adversely affects the development of the reproductive organs of male rat offspring. Thus, it is conceivable that peripubertal caffeine exposure would also influence physiologic gonadal changes and function during this critical period for sexual maturation. This study investigated the impact of high doses of caffeine on the testes of prepubertal male rats. A total of 45 immature male rats were divided randomly into three groups: a control group and 2 groups fed 120 and 180 mg/kg/day of caffeine, respectively, via the stomach for 4 weeks. Caffeine caused a significant decrease in body weight gain, accompanied by proportional decreases in lean body mass and body fat. The caffeine-fed animals had smaller and lighter testes than those of the control that were accompanied by negative influences on the histologic parameters of the testes. In addition, stimulated-testosterone ex vivo production was reduced in Leydig cells retrieved from the caffeine-fed animals. Our results demonstrate that peripubertal caffeine consumption can interfere with the maturation and function of the testis, possibly by interrupting endogenous testosterone secretion and reducing the sensitivity of Leydig cells to gonadotrophic stimulation. In addition, we confirmed that pubertal administration of caffeine reduced testis growth and altered testis histomorphology.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.