Evidence map›Paper›PMID 25983750›Full record

ReviewGastroenterology research and practice2015

Effects of Two Common Polymorphisms rs2910164 in miR-146a and rs11614913 in miR-196a2 on Gastric Cancer Susceptibility.

Qing Ni, Anlai Ji, Junfeng Yin, Xiangjun Wang, Xinnong Liu

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gastroenterology research and practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
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  3. Effect ofTechnology in cancer research & treatment
    Pooled it
  4. Article
  5. Article
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  8. Review
  9. Article
  10. Hsa-miR-449a genetic variant is associated with risk of gastric cancer in a Chinese population.International journal of clinical and experimental pathology · 2015
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Qing NiDepartment of General Surgery, First People's Hospital of Yangzhou, Yangzhou, Jiangsu 225001, China ; Department of General Surgery, The Second Medical School of Yangzhou University, Yangzhou, Jiangsu 225001, China.
Anlai JiDepartment of General Surgery, First People's Hospital of Yangzhou, Yangzhou, Jiangsu 225001, China ; Department of General Surgery, The Second Medical School of Yangzhou University, Yangzhou, Jiangsu 225001, China.ORCID 0000-0002-3680-003X
Junfeng YinDepartment of General Surgery, First People's Hospital of Yangzhou, Yangzhou, Jiangsu 225001, China ; Department of General Surgery, The Second Medical School of Yangzhou University, Yangzhou, Jiangsu 225001, China.
Xiangjun WangDepartment of General Surgery, First People's Hospital of Yangzhou, Yangzhou, Jiangsu 225001, China ; Department of General Surgery, The Second Medical School of Yangzhou University, Yangzhou, Jiangsu 225001, China.
Xinnong LiuDepartment of General Surgery, First People's Hospital of Yangzhou, Yangzhou, Jiangsu 225001, China ; Department of General Surgery, The Second Medical School of Yangzhou University, Yangzhou, Jiangsu 225001, China.
Yangzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background. Single nucleotide polymorphisms (SNPs) in genes encoding microRNAs may play important role in the development of gastric cancer. It has been reported that common SNPs rs2910164 in miR-146a and rs11614913 in miR-196a2 are associated with susceptibility to gastric cancer. The published results remain inconclusive or even controversial. A meta-analysis was conducted to quantitatively assess potential association between the two common SNPs and gastric cancer risk. Methods. A comprehensive literature search was performed in multiple internet-based electronic databases. Data from 12 eligible studies were extracted to estimate pooled odds ratios (ORs) and 95% confidence intervals (95% CI). Results. C allele of rs2910164 is associated with reduced gastric cancer risk in heterozygote model and dominant model whereas rs11614913 indicates no significant association. Subgroup analysis demonstrates that C allele of rs2910164 and rs11614913 may decrease susceptibility to diffuse type gastric cancer in dominant model and recessive model, respectively, while rs11614913 increased intestinal type gastric cancer in dominant model. Conclusion. SNPs rs2910164 and rs11614913 might have effect on gastric cancer risk in certain genetic models and specific types of cancer. Further well-designed studies should be considered to validate the potential effect.

Identifiers

PMID25983750
PMCPMC4423019
OpenAlexW1979680893

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.