ArticleFrontiers in human neuroscience2015
Sleep spindle alterations in patients with Parkinson's disease.
Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 61 citations in OpenAlex.
- Trial
- The Effects of Multimodal Exercise on Sleep Quality and Architecture, Motor Function, Cognition, Fatigue, and Systemic Inflammation in Corticobasal Syndrome: A Case Report.Physical therapy · 2025Article
- Sleep stage mixing is associated with poor prognosis in early Parkinson's disease.NPJ Parkinson's disease · 2025Article
- Sleep spindle variation in patients with Parkinson's disease on first nights of sub-optimal deep brain stimulation.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Sleep spindle density and temporal clustering are associated with sleep-dependent memory consolidation in Parkinson's disease.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Factors affecting discrepancies between scorers in manual sleep spindle detections in single-channel electroencephalography in young adult males.Frontiers in sleep · 2024Article
- Quantitative Sleep Electroencephalogram in Parkinson's Disease: A Case-Control Study.Journal of Parkinson's disease · 2023Article
- Quantitative sleep electroencephalogram and cognitive performance in Parkinson's disease with and without rapid eye movement sleep behavior disorder.Frontiers in neurology · 2023Article
- Assessment of Cognitive Function with Sleep Spindle Characteristics in Adults with Epilepsy.Neural plasticity · 2023Article
- Effects of deep brain stimulation on quantitative sleep electroencephalogram during non-rapid eye movement in Parkinson's disease.Frontiers in human neuroscience · 2023Article
- Article
- Sleep and circadian rhythms in Parkinson's disease and preclinical models.Molecular neurodegeneration · 2022Review
- Basal Ganglia Local Field Potentials as a Potential Biomarker for Sleep Disturbance in Parkinson's Disease.Frontiers in neurology · 2021Review
- New and Emerging Approaches to Better Define Sleep Disruption and Its Consequences.Frontiers in neuroscience · 2021Review
- A Novel Application of Ketamine for Improving Perioperative Sleep Disturbances.Nature and science of sleep · 2021Review
- Sleep Spindles and Fragmented Sleep as Prodromal Markers in a Preclinical Model of LRRK2-G2019S Parkinson's Disease.Frontiers in neurology · 2020Article
- Sleep in Parkinson's disease.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Review
- Assessment of Sleep Spindle Density among Genetically Positive Spinocerebellar Ataxias Types 1, 2, and 3 Patients.Annals of neurosciences · 2018Article
- Stimulus-induced transitions between spike-wave discharges and spindles with the modulation of thalamic reticular nucleus.Journal of computational neuroscience · 2017Article
- Heterozygosity for the Mood Disorder-Associated Variant Gln460Arg Alters P2X7 Receptor Function and Sleep Quality.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThe aim of this study was to identify changes of sleep spindles (SS) in the EEG of patients with Parkinson's disease (PD). Five sleep experts manually identified SS at a central scalp location (C3-A2) in 15 PD and 15 age- and sex-matched control subjects. Each SS was given a confidence score, and by using a group consensus rule, 901 SS were identified and characterized by their (1) duration, (2) oscillation frequency, (3) maximum peak-to-peak amplitude, (4) percent-to-peak amplitude, and (5) density. Between-group comparisons were made for all SS characteristics computed, and significant changes for PD patients vs. control subjects were found for duration, oscillation frequency, maximum peak-to-peak amplitude and density. Specifically, SS density was lower, duration was longer, oscillation frequency slower and maximum peak-to-peak amplitude higher in patients vs. CONTROLS: We also computed inter-expert reliability in SS scoring and found a significantly lower reliability in scoring definite SS in patients when compared to controls. How neurodegeneration in PD could influence SS characteristics is discussed. We also note that the SS morphological changes observed here may affect automatic detection of SS in patients with PD or other neurodegenerative disorders (NDDs).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.