Evidence map›Paper›PMID 25983682›Full record

ArticleFrontiers in human neuroscience2015

Age-related striatal BOLD changes without changes in behavioral loss aversion.

Vijay Viswanathan, Sang Lee, Jodi M Gilman, Byoung Woo Kim, Nick Lee, Laura Chamberlain, Sherri L Livengood, Kalyan Raman, Myung Joo Lee, Jake Kuster and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in human neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Vijay ViswanathanMedill Integrated Marketing Communications, Northwestern University Evanston, IL, USA ; Applied Neuromarketing Consortium: Northwestern University, Wayne State University, University of Michigan, Loughborough University School of Business and Economics (UK) and Massachusetts General Hospital/Harvard University Chicago, IL, USA.
Sang LeeMood and Motor Control Laboratory or Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital Boston, MA, USA ; Warren Wright Adolescent Center, Department of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine Chicago, IL, USA ; Northwestern University and Massachusetts General Hospital Phenotype Genotype Project in Addiction and Mood Disorders Chicago, IL, USA.
Jodi M GilmanMood and Motor Control Laboratory or Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital Boston, MA, USA.
Byoung Woo KimApplied Neuromarketing Consortium: Northwestern University, Wayne State University, University of Michigan, Loughborough University School of Business and Economics (UK) and Massachusetts General Hospital/Harvard University Chicago, IL, USA ; Mood and Motor Control Laboratory or Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital Boston, MA, USA ; Warren Wright Adolescent Center, Department of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine Chicago, IL, USA ; Northwestern University and Massachusetts General Hospital Phenotype Genotype Project in Addiction and Mood Disorders Chicago, IL, USA.
Nick LeeApplied Neuromarketing Consortium: Northwestern University, Wayne State University, University of Michigan, Loughborough University School of Business and Economics (UK) and Massachusetts General Hospital/Harvard University Chicago, IL, USA ; Marketing Group, Aston Business School Birmingham, UK.
Laura ChamberlainApplied Neuromarketing Consortium: Northwestern University, Wayne State University, University of Michigan, Loughborough University School of Business and Economics (UK) and Massachusetts General Hospital/Harvard University Chicago, IL, USA ; Marketing Group, Aston Business School Birmingham, UK.
Sherri L LivengoodApplied Neuromarketing Consortium: Northwestern University, Wayne State University, University of Michigan, Loughborough University School of Business and Economics (UK) and Massachusetts General Hospital/Harvard University Chicago, IL, USA ; Warren Wright Adolescent Center, Department of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine Chicago, IL, USA.
Kalyan RamanMedill Integrated Marketing Communications, Northwestern University Evanston, IL, USA ; Applied Neuromarketing Consortium: Northwestern University, Wayne State University, University of Michigan, Loughborough University School of Business and Economics (UK) and Massachusetts General Hospital/Harvard University Chicago, IL, USA ; Warren Wright Adolescent Center, Department of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine Chicago, IL, USA ; Department of Marketing, Kellogg School of Management, Northwestern University Evanston, IL, USA.
Myung Joo LeeApplied Neuromarketing Consortium: Northwestern University, Wayne State University, University of Michigan, Loughborough University School of Business and Economics (UK) and Massachusetts General Hospital/Harvard University Chicago, IL, USA ; Mood and Motor Control Laboratory or Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital Boston, MA, USA ; Warren Wright Adolescent Center, Department of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine Chicago, IL, USA ; Northwestern University and Massachusetts General Hospital Phenotype Genotype Project in Addiction and Mood Disorders Chicago, IL, USA.
Jake KusterMood and Motor Control Laboratory or Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital Boston, MA, USA ; Northwestern University and Massachusetts General Hospital Phenotype Genotype Project in Addiction and Mood Disorders Chicago, IL, USA.
Daniel B SternApplied Neuromarketing Consortium: Northwestern University, Wayne State University, University of Michigan, Loughborough University School of Business and Economics (UK) and Massachusetts General Hospital/Harvard University Chicago, IL, USA ; Warren Wright Adolescent Center, Department of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine Chicago, IL, USA.
Bobby CalderApplied Neuromarketing Consortium: Northwestern University, Wayne State University, University of Michigan, Loughborough University School of Business and Economics (UK) and Massachusetts General Hospital/Harvard University Chicago, IL, USA ; Department of Marketing, Kellogg School of Management, Northwestern University Evanston, IL, USA.
Frank J MulhernMedill Integrated Marketing Communications, Northwestern University Evanston, IL, USA ; Applied Neuromarketing Consortium: Northwestern University, Wayne State University, University of Michigan, Loughborough University School of Business and Economics (UK) and Massachusetts General Hospital/Harvard University Chicago, IL, USA.
Anne J BloodApplied Neuromarketing Consortium: Northwestern University, Wayne State University, University of Michigan, Loughborough University School of Business and Economics (UK) and Massachusetts General Hospital/Harvard University Chicago, IL, USA ; Mood and Motor Control Laboratory or Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital Boston, MA, USA ; Northwestern University and Massachusetts General Hospital Phenotype Genotype Project in Addiction and Mood Disorders Chicago, IL, USA.
Hans C BreiterApplied Neuromarketing Consortium: Northwestern University, Wayne State University, University of Michigan, Loughborough University School of Business and Economics (UK) and Massachusetts General Hospital/Harvard University Chicago, IL, USA ; Mood and Motor Control Laboratory or Laboratory of Neuroimaging and Genetics, Department of Psychiatry, Massachusetts General Hospital Boston, MA, USA ; Warren Wright Adolescent Center, Department of Psychiatry and Behavioral Science, Northwestern University Feinberg School of Medicine Chicago, IL, USA ; Northwestern University and Massachusetts General Hospital Phenotype Genotype Project in Addiction and Mood Disorders Chicago, IL, USA.

Funding

Neurobehavioral Characterization of Social Influence in Drug AddictionK01DA034093 · NIDA · MASSACHUSETTS GENERAL HOSPITAL · PI GILMAN, JODI · 2013 to 2017
$925k
NIDA NIH HHS K01 DA034093
6 · The paper itself

Abstract

Loss aversion (LA), the idea that negative valuations have a higher psychological impact than positive ones, is considered an important variable in consumer research. The literature on aging and behavior suggests older individuals may show more LA, although it is not clear if this is an effect of aging in general (as in the continuum from age 20 and 50 years), or of the state of older age (e.g., past age 65 years). We also have not yet identified the potential biological effects of aging on the neural processing of LA. In the current study we used a cohort of subjects with a 30 year range of ages, and performed whole brain functional MRI (fMRI) to examine the ventral striatum/nucleus accumbens (VS/NAc) response during a passive viewing of affective faces with model-based fMRI analysis incorporating behavioral data from a validated approach/avoidance task with the same stimuli. Our a priori focus on the VS/NAc was based on (1) the VS/NAc being a central region for reward/aversion processing; (2) its activation to both positive and negative stimuli; (3) its reported involvement with tracking LA. LA from approach/avoidance to affective faces showed excellent fidelity to published measures of LA. Imaging results were then compared to the behavioral measure of LA using the same affective faces. Although there was no relationship between age and LA, we observed increasing neural differential sensitivity (NDS) of the VS/NAc to avoidance responses (negative valuations) relative to approach responses (positive valuations) with increasing age. These findings suggest that a central region for reward/aversion processing changes with age, and may require more activation to produce the same LA behavior as in younger individuals, consistent with the idea of neural efficiency observed with high IQ individuals showing less brain activation to complete the same task.

Indexed as

agingfMRIloss aversionneurocompensationnucleus accumbensreward

Identifiers

PMID25983682
PMCPMC4415398

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.