ArticleGenetics and molecular biology2015
Association study of folate-related enzymes (MTHFR, MTR, MTRR) genetic variants with non-obstructive male infertility in a Polish population.
Article in Genetics and molecular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed, 8 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- MTHFR C677T、MTHFR A1298C、MTRR A66G and MTR A2756G polymorphisms and male infertility risk: a systematic review and meta-analysis.Reproductive biology and endocrinology : RB&E · 2024Pooled it
- Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and male infertility risk: An updated meta-analysis.Medicine · 2020Pooled it
- Association of the MTHFR 677C>T and 1298A>C polymorphisms and male infertility risk: a meta-analysis.Reproductive biology and endocrinology : RB&E · 2020Pooled it
- Contribution of MTR A2756G polymorphism and MTRR A66G polymorphism to the risk of idiopathic male infertility.Medicine · 2019Pooled it
- The susceptibility of FSHB -211G > T and FSHR G-29A, 919A > G, 2039A > G polymorphisms to men infertility: an association study and meta-analysis.BMC medical genetics · 2017Pooled it
- Association between MTHFR A1298C polymorphism and male infertility: A meta-analysis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2017Pooled it
- MTHFR C677T, A1298C and MS A2756G Gene Polymorphisms and Male Infertility Risk in a Chinese Population: A Meta-Analysis.PloS one · 2017Pooled it
- Association ofAmerican journal of men's healthPooled it
- Xenobiotic metabolizing gene variants and the risk of male infertility - A systematic review, meta-analysis andToxicology reports · 2025Review
- Article
- Correlation of MTHFR C677T Polymorphism with Male Infertility among Indian Population: Case-Control Study.Journal of pharmacy & bioallied sciences · 2024Article
- MTHFR Gene-Polymorphism and Infertile Men in Indian Population: A Systematic Literature Review.Cureus · 2022Review
- A Association ofInternational journal of fertility & sterility · 2021Article
- Correlation between methylenetetrahydrofolate reductase gene polymorphism and oligoasthenospermia and the effects of folic acid supplementation on semen quality.Translational andrology and urology · 2019Article
- Investigation of the association of idiopathic male infertility with polymorphisms in the methionine synthase (MTR) gene.Clinical and experimental reproductive medicine · 2019Article
- Analysis of genetic polymorphism of methylenetetrahydrofolate reductase in a large ethnic Hakka population in southern China.Medicine · 2018Article
- Association ofInternational journal of clinical and experimental pathology · 2017Article
- Association of theBalkan journal of medical genetics : BJMG · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Spermatogenesis is a process where an important contribution of genes involved in folate-mediated one-carbon metabolism is observed. The aim of the present study was to investigate the association between male infertility and the MTHFR (677C > T; 1298A > C), MTR (2756A > G) and MTRR (66A > G) polymorphisms in a Polish population. No significant differences in genotype or allele frequencies were detected between the groups of 284 infertile men and of 352 fertile controls. These results demonstrate that common polymorphisms in folate pathway genes are not major risk factors for non-obstructive male infertility in the Polish population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.