ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2015
Improved biomechanical and biological outcomes in the MRL/MpJ murine strain following a full-length patellar tendon injury.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
18 citing papers in PubMed.
- The superior healing capacity of MRL tendons is minimally influenced by the systemic environment of the MRL mouse.Scientific reports · 2023Article
- Earlier proteoglycan turnover promotes higher efficiency matrix remodeling in MRL/MpJ tendons.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2023Article
- Detergent-Free Decellularization Preserves the Mechanical and Biological Integrity of Murine Tendon.Tissue engineering. Part C, Methods · 2022Article
- Regenerative Drug Discovery Using Ear Pinna Punch Wound Model in Mice.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Altered TGFB1 regulated pathways promote accelerated tendon healing in the superhealer MRL/MpJ mouse.Scientific reports · 2022Article
- MRL/MpJ tendon matrix-derived therapeutic promotes improved healing outcomes in scar-mediated canonical tendon healing.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Superior mechanical recovery in male and female MRL/MpJ tendons is associated with a unique genetic profile.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2021Article
- Innate tissue properties drive improved tendon healing in MRL/MpJ and harness cues that enhance behavior of canonical healing cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- The MRL/MpJ Mouse Strain Is Not Protected From Muscle Atrophy and Weakness After Rotator Cuff Tear.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Article
- Article
- Uncorrelated healing response of tendon and ear injuries in MRL highlight a role for the local tendon environment in driving scarless healing.Connective tissue research · 2018Article
- Drug delivery and epimorphic salamander-type mouse regeneration: A full parts and labor plan.Advanced drug delivery reviews · 2018Review
- Oxygen, Metabolism, and Regeneration: Lessons from Mice.Trends in molecular medicine · 2017Review
- Deletion of EP4 in S100a4-lineage cells reduces scar tissue formation during early but not later stages of tendon healing.Scientific reports · 2017Article
- Novel Model of Tendon Regeneration Reveals Distinct Cell Mechanisms Underlying Regenerative and Fibrotic Tendon Healing.Scientific reports · 2017Article
- The LG/J murine strain exhibits near-normal tendon biomechanical properties following a full-length central patellar tendon defect.Connective tissue research · 2016Article
- High-Throughput, Multi-Image Cryohistology of Mineralized Tissues.Journal of visualized experiments : JoVE · 2016Article
- Regenerative biology of tendon: mechanisms for renewal and repair.Current molecular biology reports · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
Musculoskeletal injuries greatly affect the U.S. population and current clinical approaches fail to restore long-term native tissue structure and function. Tissue engineering is a strategy advocated to improve tendon healing; however, the field still needs to establish biological benchmarks for assessing the effectiveness of tissue-engineered structures. Investigating superior healing models, such as the MRL/MpJ, offers the opportunity to first characterize successful healing and then apply experimental findings to tissue-engineered therapies. This study seeks to evaluate the MRL/MpJ's healing response following a central patellar tendon injury compared to wildtype. Gene expression and histology were assessed at 3, 7, and 14 days following injury and mechanical properties were measured at 2, 5, and 8 weeks. Native patellar tendon biological and mechanical properties were not different between strains. Following injury, the MRL/MpJ displayed increased mechanical properties between 5 and 8 weeks; however, early tenogenic expression patterns were not different between the strains. Furthermore, expression of the cyclin-dependent kinase inhibitor, p21, was not different between strains, suggesting an alternative mechanism may be driving the healing response. Future studies will investigate collagen structure and alignment of the repair tissue and characterize the complete healing transcriptome to identify mechanisms driving the MRL/MpJ response.
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Registered trials
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