ArticleDevelopmental cell2015
Sarcomeres Pattern Proprioceptive Sensory Dendritic Endings through UNC-52/Perlecan in C. elegans.
Article in Developmental cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 60 citations in OpenAlex.
- NLP-12/Cholecystokinin signaling stabilizes sensory dendritic structure and protects neuronal healthspan inbioRxiv : the preprint server for biology · 2026Article
- Hypergravity hinders proper dendritic patterning of a sensory neuron in the nematode Caenorhabditis elegans.Scientific reports · 2025Article
- UNC-52 localization with respect to longitudinal axon tracts in the ventral and dorsal nerve cords inmicroPublication biology · 2025Article
- Endocytosis restricts dendrite branching via removing ectopically localized branching ligands.Nature communications · 2024Article
- Dendrite morphogenesis in Caenorhabditis elegans.Genetics · 2024Review
- Convertase-dependent regulation of membrane-tethered and secreted ligands tunes dendrite adhesion.Development (Cambridge, England) · 2023Article
- MBL-1 and EEL-1 affect the splicing and protein levels of MEC-3 to control dendrite complexity.PLoS genetics · 2023Article
- Loss of the Extracellular Matrix Protein DIG-1 Causes Glial Fragmentation, Dendrite Breakage, and Dendrite Extension Defects.Journal of developmental biology · 2021Article
- Basement membrane remodeling guides cell migration and cell morphogenesis during development.Current opinion in cell biology · 2021Review
- Proprioception, the regulator of motor function.BMB reports · 2021Review
- A two-step actin polymerization mechanism drives dendrite branching.Neural development · 2021Article
- Neuron tracing and quantitative analyses of dendritic architecture reveal symmetrical three-way-junctions and phenotypes of git-1 in C. elegans.PLoS computational biology · 2021Article
- Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adultiScience · 2021Article
- Transparent Touch: Insights From Model Systems on Epidermal Control of Somatosensory Innervation.Frontiers in cellular neuroscience · 2021Review
- Mutually exclusive dendritic arbors in C. elegans neurons share a common architecture and convergent molecular cues.PLoS genetics · 2020Article
- [Intrinsic and extrinsic mechanisms regulating neuronal dendrite morphogenesis].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2020Review
- Parallel Processing of Two Mechanosensory Modalities by a Single Neuron in C. elegans.Developmental cell · 2019Article
- Mechanisms that regulate morphogenesis of a highly branched neuron in C. elegans.Developmental biology · 2019Review
- Beyond being innervated: the epidermis actively shapes sensory dendritic patterning.Open biology · 2019Review
- A conserved morphogenetic mechanism for epidermal ensheathment of nociceptive sensory neurites.eLife · 2019Article
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5 authors at 4 institutions in 3 countries.
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Abstract
Sensory dendrites innervate peripheral tissues through cell-cell interactions that are poorly understood. The proprioceptive neuron PVD in C. elegans extends regular terminal dendritic branches between muscle and hypodermis. We found that the PVD branch pattern was instructed by adhesion molecule SAX-7/L1CAM, which formed regularly spaced stripes on the hypodermal cell. The regularity of the SAX-7 pattern originated from the repeated and regularly spaced dense body of the sarcomeres in the muscle. The extracellular proteoglycan UNC-52/Perlecan linked the dense body to the hemidesmosome on the hypodermal cells, which in turn instructed the SAX-7 stripes and PVD dendrites. Both UNC-52 and hemidesmosome components exhibited highly regular stripes that interdigitated with the SAX-7 stripe and PVD dendrites, reflecting the striking precision of subcellular patterning between muscle, hypodermis, and dendrites. Hence, the muscular contractile apparatus provides the instructive cues to pattern proprioceptive dendrites.
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