ArticleThe American journal of psychiatry2015
Brain development in heavy-drinking adolescents.
Article in The American journal of psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 142 papers, 1 of them a synthesis that pooled it.
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Who cites it
142 citing papers in PubMed, 1 synthesis or guideline pooled it, 240 citations in OpenAlex.
- Neurobiological and Cognitive Profile of Young Binge Drinkers: a Systematic Review and Meta-Analysis.Neuropsychology review · 2019Pooled it
- A Randomized Controlled Trial of N-acetylcysteine for Adolescent and Young Adult Alcohol Use Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2026Trial
- Effectiveness of genetic feedback on alcohol metabolism to reduce alcohol consumption in young adults: an open-label randomized controlled trial.BMC medicine · 2024Trial
- Effective prevention programming for reducing alcohol-related harms experienced by first year college students: Evaluation of the expectancy challenge alcohol literacy curriculum (ECALC).Addictive behaviors · 2022Trial
- Oxytocin attenuates neural response to emotional faces in social drinkers: an fMRI study.European archives of psychiatry and clinical neuroscience · 2021Trial
- Effect of Middle School Interventions on Alcohol Misuse and Abuse in Mexican American High School Adolescents: Five-Year Follow-up of a Randomized Clinical Trial.JAMA psychiatry · 2018Trial
- Preventing Binge Drinking in Adolescents.Deutsches Arzteblatt international · 2017Trial
- Alexithymia mediates white-matter microstructure and substance use escalation in trauma-exposed individuals.Journal of affective disorders · 2026Article
- Underage Access to Alcohol Through Curbside and Home Delivery: Prevalence and Consequences.Prevention science : the official journal of the Society for Prevention Research · 2026Article
- A neuroimmune framework for understanding adolescent stress and risk of alcohol misuse.Brain, behavior, & immunity - health · 2026Review
- Age- and alcohol-related differences in adolescent neurometabolite levels.Alcohol, clinical & experimental research · 2026Article
- Alcohol Craving and Cue Exposure in Real Time: A Pilot Ecological Momentary Assessment (EMA)-Based Personalized Feedback Intervention for Young Adults.Journal of studies on alcohol and drugs · 2026Article
- Behavioral profile predicts ethanol preference in adolescent mice, but not in adults: A machine learning approach.Alcohol, clinical & experimental research · 2026Article
- Sex differences in the neuroimmune response following heavy, binge-like alcohol exposure in adolescent rats.Journal of neuroimmunology · 2025Article
- Variation of Myelin-associated Gene Expression andbioRxiv : the preprint server for biology · 2025Article
- Socioemotional and Executive Control Mismatch in Adolescence and Risks for Initiating Drinking.JAMA network open · 2025Article
- Personalized Feedback in Parent-Based Interventions to Prevent or Reduce Adolescent Drinking.Journal of studies on alcohol and drugs · 2025Article
- Clinical Characteristics and Treatment Outcomes of Alcohol Withdrawal Syndrome in Adolescents and Young Adults.JAACAP open · 2025Article
- The link between early-life adversity and later alcohol use disorder: A role for microglia?Neurobiology of stress · 2025Article
- Regional and temporal dynamics of DNA methylation and epigenetic gene regulation in response to binge-like alcohol exposure in the adolescent mouse brain.Frontiers in molecular neuroscience · 2025Article
82 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
objectiveHeavy alcohol use during adolescence may alter the trajectory of normal brain development. The authors measured within-subject changes in regional brain morphometry over longer intervals and in larger samples of adolescents than previously reported and assessed differences between adolescents who remained nondrinkers and those who drank heavily during adolescence as well as differences between the sexes.
methodThe authors examined gray and white matter volume trajectories in 134 adolescents, of whom 75 transitioned to heavy drinking and 59 remained light drinkers or nondrinkers over roughly 3.5 years. Each underwent MRI scanning two to six times between ages 12 and 24 and was followed for up to 8 years. The volumes of the neocortex, allocortex, and white matter structures were measured using atlas-based parcellation with longitudinal registration. Linear mixed-effects models described differences in trajectories of heavy drinkers and nondrinkers over age; secondary analyses considered the contribution of other drug use to identified alcohol use effects.
resultsHeavy-drinking adolescents showed accelerated gray matter reduction in cortical lateral frontal and temporal volumes and attenuated white matter growth of the corpus callosum and pons relative to nondrinkers. These results were largely unchanged when use of marijuana and other drugs was examined. Male and female drinkers showed similar patterns of development trajectory abnormalities.
conclusionsLongitudinal analysis enabled detection of accelerated typical volume decline in frontal and temporal cortical volumes and attenuated growth in principal white matter structures in adolescents who started to drink heavily. These results provide a call for caution regarding heavy alcohol use during adolescence, whether heavy drinking is the sole cause or one of several in these alterations in brain development.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.