ArticleParasitology research2015
Destructive effect of gamma irradiation on Echinococcus granulosus metacestodes.
Article in Parasitology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Purification and transcriptomic characterization of proliferative cells ofFrontiers in parasitology · 2024Article
- Apoptosis as a Potential Target to Arrest and Survival of Hydatid Cyst.Advanced biomedical research · 2023Article
- Study on the effect of an ion channel inhibitor "Fluralaner" onJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2020Article
- Recent advances on innate immune pathways related to host-parasite cross-talk in cystic and alveolar echinococcosis.Parasites & vectors · 2020Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Current options for treatment of cystic echinococcosis (CE), including chemotherapeutics and surgical approaches, are not satisfactory in certain cases of resistant cysts in vulnerable or inaccessible organs. Therefore, potential means of therapy are needed. The present work evaluated the effect of gamma irradiation on mestacestode causing CE. Metacestode of Echinococcus granulosus were exposed to 15, 30, and 60 Gy irradiation and examined after 24 h for viability, morphologic, and ultrastuctural alterations by light and electron microscopy. Apoptosis was determined by caspase-3 activity by colorimetric assay and immunohistochemistry. The irradiated metacestodes showed loss of viability, damage of protoscolices, formation of lipid droplets and vacuoles, and separation of the germinal layer. Apoptosis was prominent after irradiation. Our results suggested that gamma irradiation have therapeutic potential in CE. Moreover, understanding the destructive effect of irradiation may help in developing prophylactic measures against CE. Further studies are needed to test the efficacy of ionizing radiation in long-term animal models.
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