SynthesisSystematic reviews2015
Predicting developmental outcomes in premature infants by term equivalent MRI: systematic review and meta-analysis.
Synthesis in Systematic reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Pooled it
- Advanced neuroimaging and its role in predicting neurodevelopmental outcomes in very preterm infants.Seminars in perinatology · 2016Pooled it
- Effect of MRI on preterm infants and their families: a randomised trial with nested diagnostic and economic evaluation.Archives of disease in childhood. Fetal and neonatal edition · 2018Trial
- MRI and proton MR spectroscopy in neonatal hypoxic-ischemic encephalopathy: a comprehensive imaging review.Japanese journal of radiology · 2026Review
- Integrating Findings Into Practice: Assessing External Validity of Congestive Heart Failure Trials.Cardiology research · 2026Article
- Punctate white matter lesions predict risk for cerebral palsy: further evidence for routine brain MRI in preterm infants.Pediatric research · 2025Article
- Impact of fetal inflammatory response on brain MRI abnormalities in extremely preterm infants.Pediatric research · 2025Article
- White matter injury and outcomes: what is the final verdict?Pediatric research · 2025Article
- Machine learning models for neurocognitive outcome prediction in preterm born infants.Pediatric research · 2025Article
- Brain MRI before and at term equivalent age predicts motor and cognitive outcomes in very preterm infants.Neuroimage. Reports · 2025Article
- The impact of clinical seizures and adverse brain MRI patterns in neonates with hypoxic-ischemic encephalopathy and abnormal neurodevelopment.Clinics (Sao Paulo, Brazil) · 2025Article
- Predicting 2-year neurodevelopmental outcomes in preterm infants using multimodal structural brain magnetic resonance imaging with local connectivity.Scientific reports · 2024Article
- Multilabel SegSRGAN-A framework for parcellation and morphometry of preterm brain in MRI.PloS one · 2024Article
- Major Surgery, Brain Injury, and Neurodevelopmental Outcomes in Very Preterm Infants.Neurology · 2023Article
- Relationship of early brain growth pattern measured by ultrasound with neurological outcome at two years of age in very low birth weight infants.European journal of pediatrics · 2023Article
- Development of neonatal-specific sequences for portable ultralow field magnetic resonance brain imaging: a prospective, single-centre, cohort study.EClinicalMedicine · 2023Article
- Diagnostic performance of synthetic relaxometry for predicting neurodevelopmental outcomes in premature infants: a feasibility study.European radiology · 2023Article
- Term equivalent age brain MRI of preterm newborns: gathering the pieces for prognostication.European radiology · 2023Article
- Cerebral Myelination in a Bronchopulmonary Dysplasia Murine Model.Children (Basel, Switzerland) · 2023Article
- Early surgery in very preterm infants is associated with brain abnormalities on term MRI: a propensity score analysis.Journal of perinatology : official journal of the California Perinatal Association · 2023Observational
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThis study aims to determine the prognostic accuracy of term MRI in very preterm born (≤32 weeks) or low-birth-weight (≤1500 g) infants for long-term (>18 months) developmental outcomes.
methodsWe performed a systematic review searching Central, Medline, Embase, and PsycInfo. Two independent reviewers performed study selection, data extraction, and quality assessment. We documented sensitivity and specificity for three different MRI findings (white matter abnormalities (WMA), brain abnormality (BA), and diffuse excessive high signal intensity (DEHSI)), related to developmental outcomes including cerebral palsy (CP), visual and/or hearing problems, motor, neurocognitive, and behavioral function. Using bivariate meta-analysis, we estimated pooled sensitivity and specificity and plotted summary receiver operating characteristic (sROC) curves for different cut-offs of MRI.
resultsWe included 20 papers published between 2000 and 2013. Quality of included studies varied. Pooled sensitivity and specificity values (95 % confidence interval (CI)) for prediction of CP combining the three different MRI findings (using normal/mild vs. moderate/severe cut-off) were 77 % (53 to 91 %) and 79 % (51 to 93 %), respectively. For prediction of motor function, the values were 72 % (52 to 86 %) and 62 % (29 to 87 %), respectively. Prognostic accuracy for visual and/or hearing problems, neurocognitive, and/or behavioral function was poor. sROC curves of the individual MRI findings showed that presence of WMA provided the best prognostic accuracy whereas DEHSI did not show any potential prognostic accuracy.
conclusionsThis study shows that presence of moderate/severe WMA on MRI around term equivalent age can predict CP and motor function in very preterm or low-birth-weight infants with moderate sensitivity and specificity. Its ability to predict other long-term outcomes such as neurocognitive and behavioral impairments is limited. Also, other white matter related tests as BA and DEHSI demonstrated limited prognostic value. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42013006362.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.