ArticleActa paediatrica (Oslo, Norway : 1992)2015
Maternal obesity and development of the preterm newborn at 2 years.
Article in Acta paediatrica (Oslo, Norway : 1992), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Maternal pre-pregnancy obesity and childhood physical and cognitive development of children: a systematic review.International journal of obesity (2005) · 2016Pooled it
- Current states in understanding oligodendroglia-mediated neurological issues in neurofibromatosis type 1 (NF1).Acta neuropathologica communications · 2025Review
- Possible relationship between pre-pregnancy maternal body mass index and offspring hippocampus: An experimental study in albino Wistar rat.Open veterinary journal · 2024Article
- The association of maternal overweight on long-term neurodevelopmental outcomes in premature infants (< 29 weeks) at 18-24 months corrected age.Journal of perinatology : official journal of the California Perinatal Association · 2023Article
- The contributions of parental lactation on offspring development: It's not udder nonsense!Hormones and behavior · 2023Review
- Maternal pre-pregnancy obesity affects the uncinate fasciculus white matter tract in preterm infants.Frontiers in pediatrics · 2023Article
- In-hospital mortality and morbidity among extremely preterm infants in relation to maternal body mass index.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Placental programming, perinatal inflammation, and neurodevelopment impairment among those born extremely preterm.Pediatric research · 2021Review
- Genetic and epigenetic factors and early life inflammation as predictors of neurodevelopmental outcomes.Seminars in fetal & neonatal medicine · 2020Review
- Maternal Overweight, Inflammation and Neurological Consequences for the Preterm Child: Results of the ELGAN Study.Geburtshilfe und Frauenheilkunde · 2019Article
- Accuracy of the Bayley-II mental development index at 2 years as a predictor of cognitive impairment at school age among children born extremely preterm.Journal of perinatology : official journal of the California Perinatal Association · 2018Observational
- Maternal body mass index and risk of intraventricular hemorrhage in preterm infants.Pediatric research · 2018Article
- The Relationship of Maternal Prepregnancy Body Mass Index and Pregnancy Weight Gain to Neurocognitive Function at Age 10 Years among Children Born Extremely Preterm.The Journal of pediatrics · 2017Article
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6 authors.
Funding
Abstract
aimTo evaluate to what extent extremely preterm children (<28 weeks' gestational age) of overweight (BMI 25-29) or obese (BMI ≥30) women are at increased risk of adverse development at 2 years measured with the Bayley Scales of Infant Development II in a multicenter prospective cohort study.
methodsHeights and prepregnancy weights of the mothers of 852 preterm born children were collected and included in multinomial logistic regression models.
resultsCompared to newborns born to mothers with normal BMIs, newborns of obese mothers, but not those of overweight mothers, were more likely to have Bayley Scales indices more than 3 standard deviations below the reference mean (mental: OR = 2.1; 95% CI: 1.3, 3.5) (motor: OR = 1.7; 95% CI: 1.1, 2.7). These associations were even more prominent in children who did not have the intermittent or sustained systemic inflammation profile previously shown to be associated with severely impaired development (mental: OR = 4.6; 95% CI: 1.6, 14) (motor: OR = 3.7; 95% CI: 1.5, 8.9).
conclusionMaternal obesity is associated with an increased risk of impaired offspring development. Some of this impaired development cannot be attributed to confounding due to immaturity, socio-economic correlates or neonatal systemic inflammation.
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