ArticleBiomechanics and modeling in mechanobiology2016
Foam-like compression behavior of fibrin networks.
Article in Biomechanics and modeling in mechanobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- Discovering the Effects of Superior-Surface Vocal Fold Lesions via Fluid-Structure Interaction Analysis.Bioengineering (Basel, Switzerland) · 2025Article
- Shape Memory Collagen Scaffolds Sustain Large-Scale Cyclic Loading.ACS materials letters · 2025Article
- Fluid effects on the fracture toughness of gels.Journal of the mechanics and physics of solids · 2025Article
- Article
- Rupture mechanics of blood clot fibrin fibers: A coarse-grained model study.Journal of the mechanics and physics of solids · 2025Article
- Hyperelasticity of blood clots: Bridging the gap between microscopic and continuum scales.Journal of the mechanics and physics of solids · 2024Article
- Compressive instabilities enable cell-induced extreme densification patterns in the fibrous extracellular matrix: Discrete model predictions.PLoS computational biology · 2024Article
- Flow affects the structural and mechanical properties of the fibrin network in plasma clots.Journal of materials science. Materials in medicine · 2024Article
- Combined computational modeling and experimental study of the biomechanical mechanisms of platelet-driven contraction of fibrin clots.Communications biology · 2023Article
- Dynamic remodeling of fiber networks with stiff inclusions under compressive loading.Acta biomaterialia · 2023Article
- Fracture toughness of fibrin gels as a function of protein volume fraction: Mechanical origins.Acta biomaterialia · 2023Article
- Effect of hyaluronic acid on microscale deformations of collagen gels.Journal of the mechanical behavior of biomedical materials · 2022Article
- Biomechanical origins of inherent tension in fibrin networks.Journal of the mechanical behavior of biomedical materials · 2022Article
- Rheology of fibrous gels under compression.Extreme Mechanics Letters · 2022Article
- Computational Biomechanical Modeling of Fibrin Networks and Platelet-Fiber Network Interactions.Current opinion in biomedical engineering · 2022Article
- Cells exploit a phase transition to mechanically remodel the fibrous extracellular matrix.Journal of the Royal Society, Interface · 2021Article
- Fibrinogen and Fibrin.Sub-cellular biochemistry · 2021Review
- Analysis of the foam-forming of non-woven lightweight fibrous materials using X-ray tomography.SN applied sciences · 2021Article
- Fibrous gels modelled as fluid-filled continua with double-well energy landscape.Proceedings. Mathematical, physical, and engineering sciences · 2020Article
- Rupture of blood clots: Mechanics and pathophysiology.Science advances · 2020Article
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Authors and funding
6 authors.
Funding
Abstract
The rheological properties of fibrin networks have been of long-standing interest. As such there is a wealth of studies of their shear and tensile responses, but their compressive behavior remains unexplored. Here, by characterization of the network structure with synchronous measurement of the fibrin storage and loss moduli at increasing degrees of compression, we show that the compressive behavior of fibrin networks is similar to that of cellular solids. A nonlinear stress-strain response of fibrin consists of three regimes: (1) an initial linear regime, in which most fibers are straight, (2) a plateau regime, in which more and more fibers buckle and collapse, and (3) a markedly nonlinear regime, in which network densification occurs by bending of buckled fibers and inter-fiber contacts. Importantly, the spatially non-uniform network deformation included formation of a moving "compression front" along the axis of strain, which segregated the fibrin network into compartments with different fiber densities and structure. The Young's modulus of the linear phase depends quadratically on the fibrin volume fraction while that in the densified phase depends cubically on it. The viscoelastic plateau regime corresponds to a mixture of these two phases in which the fractions of the two phases change during compression. We model this regime using a continuum theory of phase transitions and analytically predict the storage and loss moduli which are in good agreement with the experimental data. Our work shows that fibrin networks are a member of a broad class of natural cellular materials which includes cancellous bone, wood and cork.
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