Evidence map›Paper›PMID 25982422›Full record

ArticleJournal of assisted reproduction and genetics2015

Ovarian hyperstimulation syndrome after gonadotropin-releasing hormone agonist triggering and "freeze-all": in-depth analysis of genetic predisposition.

Samuel Santos-Ribeiro, Nikolaos P Polyzos, Katrien Stouffs, Michel De Vos, Sara Seneca, Herman Tournaye, Christophe Blockeel

Open access · greenAbstract readCase Reports
In one paragraph

Article in Journal of assisted reproduction and genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
6.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. The state of "freeze-for-all" in human ARTs.Journal of assisted reproduction and genetics · 2016
    Review
  12. Does freeze all policy eliminate OHSS??? "It ain't necessarily so…".Journal of assisted reproduction and genetics · 2015
    Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 2 countries.

Samuel Santos-RibeiroCentre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090, Brussels, Belgium.
Nikolaos P Polyzos
Katrien Stouffs
Michel De Vos
Sara Seneca
Herman Tournaye
Christophe Blockeel
Vrije Universiteit Brussel · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe report on the results of the whole-genome analysis performed in a patient who developed severe ovarian hyperstimulation syndrome (OHSS) following gonadotropin-releasing hormone (GnRH) agonist triggering in a "freeze-all" protocol.

methodsA 30-year-old patient with polycystic ovary syndrome who developed severe early-onset OHSS with clinical ascites, and slight renal and hepatic dysfunction was admitted for monitoring and treatment with cabergoline and intravenous albumin. Exome sequencing to assess for any known genetic predisposition for OHSS was performed.

resultsNo known genetic variants associated with OHSS predisposition were found.

conclusionsCase reports of severe OHSS following a "freeze-all" strategy are starting to arise, showing that OHSS has not been completely eliminated with this approach. Further studies should be conducted to confirm if such cases may be due to genetic predisposition or not.

Indexed as

Genetic Predisposition to DiseaseAdultFemaleGenome, HumanGonadotropin-Releasing HormoneHumansMaleOocyte RetrievalOvarian Hyperstimulation SyndromePolycystic Ovary SyndromePregnancySperm Injections, IntracytoplasmicGonadotropin-Releasing Hormone

Identifiers

PMID25982422
PMCPMC4531869
OpenAlexW331187080

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.