ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2015
Allelic variants in the PRR37 gene and the human-mediated dispersal and diversification of sorghum.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Toward Breeding by Gene Design: Constructing the Ideotype ofPlants (Basel, Switzerland) · 2026Review
- Genes and pathways determining flowering time variation in temperate-adapted sorghum.The Plant journal : for cell and molecular biology · 2025Article
- Deleterious mutations predicted in the sorghum (Sorghum bicolor) Maturity (Ma) and Dwarf (Dw) genes from whole-genome resequencing.Scientific reports · 2023Article
- Review
- Molecular Links between Flowering and Abiotic Stress Response: A Focus onPlants (Basel, Switzerland) · 2023Review
- The recent evolutionary rescue of a staple crop depended on over half a century of global germplasm exchange.Science advances · 2022Article
- Isolation and identification ofFrontiers in plant science · 2022Article
- High-depth resequencing of 312 accessions reveals the local adaptation of foxtail millet.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Genetic characterization of a Sorghum bicolor multiparent mapping population emphasizing carbon-partitioning dynamics.G3 (Bethesda, Md.) · 2021Article
- Stepwise selection on homeologous PRR genes controlling flowering and maturity during soybean domestication.Nature genetics · 2020Article
- Positional Cloning of the Flowering Time QTLFrontiers in plant science · 2019Article
- Genomic and environmental determinants and their interplay underlying phenotypic plasticity.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messageAllele phylogenetic analysis of the sorghum flowering-time gene PRR37 provided new insight into the human-mediated selection of a key adaptive gene that occurred during sorghum's diversification and worldwide dispersal. The domestication and spread of the tropical cereal sorghum is associated with the historic movement of humans. We show that an allelic series at PRR37 (pseudo-response regulator 37), a circadian clock-associated transcription factor, was selected in long-day ecosystems worldwide to permit floral initiation and grain production. We identified a series of loss-of-function (photoperiod-insensitive) alleles encoding truncated PRR37 proteins, alleles with key amino acid substitutions in the pseudo-receiver domain, and a novel splice variant in which the pseudo-receiver domain is truncated. Each PRR37 allelic variant was traced to a specific geographic location or specialized agronomic type. We present a graphical model that shows evidence of human selection and gene flow of the PRR37 allelic variants during the global dispersal and agronomic diversification of sorghum. With the recent identification of the Ghd7 gene as an important regulator of flowering date in sorghum, we briefly examine whether loss-of-function Ghd7 allelic variants were selected prior to the human-mediated movement of sorghum from its equatorial center of origin to temperate climates worldwide.
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