Evidence map›Paper›PMID 25982045›Full record

ArticleThe Journal of surgical research2015

Kidney Disease Improving Global Outcomes guidelines and parathyroidectomy for renal hyperparathyroidism.

Sarah C Oltmann, Tariq M Madkhali, Rebecca S Sippel, Herbert Chen, David F Schneider

Abstract readEvaluation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of surgical research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Diagnostics (Basel, Switzerland) · 2023
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Acute neurological syndrome complicating secondary hyperparathyroidism.Proceedings (Baylor University. Medical Center) · 2018
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Sarah C OltmannDepartment of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas. Electronic address: Sarah.Oltmann@utsouthwestern.edu.
Tariq M MadkhaliDepartment of Surgery, University of Wisconsin, Madison, Wisconsin.
Rebecca S SippelDepartment of Surgery, University of Wisconsin, Madison, Wisconsin.
Herbert ChenDepartment of Surgery, University of Wisconsin, Madison, Wisconsin.
David F SchneiderDepartment of Surgery, University of Wisconsin, Madison, Wisconsin.
University of Wisconsin–Madison · USSouthwestern Medical Center · US

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Institutional Clinical and Translational Science AwardKL2TR000428 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$6.2M
NCATS NIH HHS KL2 TR000428NCATS NIH HHS KL2TR000428NCATS NIH HHS UL1 TR000427NCATS NIH HHS UL1TR000427
6 · The paper itself

Abstract

backgroundPatients with end-stage renal disease develop hypocalcemia, resulting in secondary hyperparathyroidism (SHPT). No clear criterions exist to aid in surgical decision making for SHPT. The 2009 Kidney Disease Improving Global Outcomes (KDIGO) guidelines provide target ranges for serum calcium, phosphate, and parathyroid hormone (PTH) levels in patients with end-stage renal disease. Parathyroidectomy can help achieve these targets. The study purpose was to examine how parathyroidectomy for SHPT impacts KDIGO targets during immediate and long-term follow-up and to evaluate KDIGO categorization with receipt of additional surgical intervention.

methodsA retrospective review of a prospective parathyroidectomy database was performed. Included patients had SHPT, were on dialysis, and underwent parathyroidectomy. Calcium, phosphate, and PTH values were classified as below, within, or above KDIGO targets.

resultsBetween 2000 and 2013, 36 patients with SHPT met criteria. Subtotal parathyroidectomy was performed in 89%, total parathyroidectomy in 11%. Follow-up time was 54 ± 7 mo. Eight patients (22%) required additional surgery. Twenty-eight patients (76%) were alive at the last follow-up. At the last-follow up, patients had phosphate (46%), and PTH (17%) above KDIGO ranges. Factors associated with reoperation were assessed. Patient PTH within or above target immediately postoperative had a higher rate of reoperation (P < 0.01). At the last follow-up, higher phosphate (P = 0.054) and PTH (P < 0.001) were associated with higher reoperation rates, but calcium (P = 0.33) was not.

conclusionsPTH and phosphate levels above KDIGO indices were associated with additional surgical intervention. Many patients had laboratory indices above range at the last follow up, suggesting more patients had persistent or recurrent disease than those who underwent reoperation. Patients may benefit from more aggressive medical and/or surgical management.

Indexed as

ParathyroidectomyAdultAgedBiomarkersCalciumFemaleFollow-Up StudiesHumansHyperparathyroidism, SecondaryKidney Failure, ChronicMaleMiddle AgedParathyroid HormonePhosphatesPractice Guidelines as TopicRecurrenceBiomarkersCalciumParathyroid HormonePhosphatesKDIGOMineral and bone disorderParathyroidectomyRenal hyperparathyroidismSecondary hyperparathyroidism

Identifiers

PMID25982045
PMCPMC4604005
OpenAlexW1837748849

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.